Spatiotemporal analysis of axonal autophagosome–lysosome dynamics reveals limited fusion events and slow maturation

Macroautophagy is a homeostatic process required to clear cellular waste. Neuronal autophagosomes form constitutively in the distal tip of the axon and are actively transported toward the soma, with cargo degradation initiated en route. Cargo turnover requires autophagosomes to fuse with lysosomes t...

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Detalles Bibliográficos
Autores principales: Cason, Sydney E., Mogre, Saurabh S., Holzbaur, Erika L. F., Koslover, Elena F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634976/
https://www.ncbi.nlm.nih.gov/pubmed/36044338
http://dx.doi.org/10.1091/mbc.E22-03-0111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634976/
https://www.ncbi.nlm.nih.gov/pubmed/36044338
http://dx.doi.org/10.1091/mbc.E22-03-0111

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