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A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase

RNF5 E3 ubiquitin ligase has multiple biological roles and has been linked to the development of severe diseases such as cystic fibrosis, acute myeloid leukemia, and certain viral infections, emphasizing the importance of discovering small-molecule RNF5 modulators for research and drug development....

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Detalles Bibliográficos
Autores principales:	Ruan, Jingjing, Liang, Dongdong, Yan, Wenjing, Zhong, Yongwang, Talley, Daniel C., Rai, Ganesha, Tao, Dingyin, LeClair, Christopher A., Simeonov, Anton, Zhang, Yinghua, Chen, Feihu, Quinney, Nancy L., Boyles, Susan E., Cholon, Deborah M., Gentzsch, Martina, Henderson, Mark J., Xue, Fengtian, Fang, Shengyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634977/ https://www.ncbi.nlm.nih.gov/pubmed/36074076 http://dx.doi.org/10.1091/mbc.E22-06-0233

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