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Trem2 deficiency impairs recovery and phagocytosis and dysregulates myeloid gene expression during virus-induced demyelination

BACKGROUND: Triggering receptor expressed on myeloid cells 2 (Trem2) plays a protective role in neurodegenerative diseases. By contrast, Trem2 functions can exacerbate tissue damage during respiratory viral or liver infections. We, therefore, investigated the role of Trem2 in a viral encephalomyelit...

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Detalles Bibliográficos
Autores principales:	Hwang, Mihyun, Savarin, Carine, Kim, Jihye, Powers, Jennifer, Towne, Natasha, Oh, Hyunsuk, Bergmann, Cornelia C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635103/ https://www.ncbi.nlm.nih.gov/pubmed/36333761 http://dx.doi.org/10.1186/s12974-022-02629-1

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