The effect of endometriosis on fertility in an animal model

The present experimental model aimed to investigate the possible effect of endometriosis on ovarian function by altering follicular maturation and development. This single-blind, randomized study included twenty-four female Sprague Dawley rats, 2.5 months old, weighing 160–200 grams. The animals wer...

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Detalles Bibliográficos
Autores principales: Kanellopoulos, Dimitrios, Karagianni, Dimitra, Pergialiotis, Vasilios, Nikiteas, Nikolaos, Lazaris, Andreas C, Iliopoulos, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635238/
https://www.ncbi.nlm.nih.gov/pubmed/36415526
http://dx.doi.org/10.25122/jml-2021-0391
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author Kanellopoulos, Dimitrios
Karagianni, Dimitra
Pergialiotis, Vasilios
Nikiteas, Nikolaos
Lazaris, Andreas C
Iliopoulos, Dimitrios
author_facet Kanellopoulos, Dimitrios
Karagianni, Dimitra
Pergialiotis, Vasilios
Nikiteas, Nikolaos
Lazaris, Andreas C
Iliopoulos, Dimitrios
author_sort Kanellopoulos, Dimitrios
collection PubMed
description The present experimental model aimed to investigate the possible effect of endometriosis on ovarian function by altering follicular maturation and development. This single-blind, randomized study included twenty-four female Sprague Dawley rats, 2.5 months old, weighing 160–200 grams. The animals were randomly separated into four groups on the day of the surgery. Each group consisted of 6 rats. The first group (A) consisted of healthy female rats (control group). The second group (B) consisted of rats subjected to surgical insertion of ovarian endometrioma. The third group (C) consisted of rats subjected to surgically induced diffuse intraperitoneal endometriosis, and the fourth group (D) consisted of rats subjected to surgically induced extraperitoneal endometriosis. According to our experimental model, endometriosis may affect ovarian function by increasing the number of luteinized unruptured follicles (follicles that have undergone luteinization without prior rupture).
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spelling pubmed-96352382022-11-21 The effect of endometriosis on fertility in an animal model Kanellopoulos, Dimitrios Karagianni, Dimitra Pergialiotis, Vasilios Nikiteas, Nikolaos Lazaris, Andreas C Iliopoulos, Dimitrios J Med Life Original Article The present experimental model aimed to investigate the possible effect of endometriosis on ovarian function by altering follicular maturation and development. This single-blind, randomized study included twenty-four female Sprague Dawley rats, 2.5 months old, weighing 160–200 grams. The animals were randomly separated into four groups on the day of the surgery. Each group consisted of 6 rats. The first group (A) consisted of healthy female rats (control group). The second group (B) consisted of rats subjected to surgical insertion of ovarian endometrioma. The third group (C) consisted of rats subjected to surgically induced diffuse intraperitoneal endometriosis, and the fourth group (D) consisted of rats subjected to surgically induced extraperitoneal endometriosis. According to our experimental model, endometriosis may affect ovarian function by increasing the number of luteinized unruptured follicles (follicles that have undergone luteinization without prior rupture). Carol Davila University Press 2022-09 /pmc/articles/PMC9635238/ /pubmed/36415526 http://dx.doi.org/10.25122/jml-2021-0391 Text en ©2022 JOURNAL of MEDICINE and LIFE https://creativecommons.org/licenses/by/3.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Original Article
Kanellopoulos, Dimitrios
Karagianni, Dimitra
Pergialiotis, Vasilios
Nikiteas, Nikolaos
Lazaris, Andreas C
Iliopoulos, Dimitrios
The effect of endometriosis on fertility in an animal model
title The effect of endometriosis on fertility in an animal model
title_full The effect of endometriosis on fertility in an animal model
title_fullStr The effect of endometriosis on fertility in an animal model
title_full_unstemmed The effect of endometriosis on fertility in an animal model
title_short The effect of endometriosis on fertility in an animal model
title_sort effect of endometriosis on fertility in an animal model
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635238/
https://www.ncbi.nlm.nih.gov/pubmed/36415526
http://dx.doi.org/10.25122/jml-2021-0391
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