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Clinical characteristics of combined rosacea and migraine
BACKGROUND: An overlap between the skin disease rosacea and the headache disease migraine has been established; however, the magnitude of this overlap and the distribution between subtypes/phenotypes remains unclear. OBJECTIVE: The aim was to determine the magnitude of the overlap between rosacea an...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635264/ https://www.ncbi.nlm.nih.gov/pubmed/36341245 http://dx.doi.org/10.3389/fmed.2022.1026447 |
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author | Wienholtz, Nita K. F. Christensen, Casper E. Zhang, Ditte G. Rechnagel, Anne-Sofie A. Byrnel, Helene V. S. Haugaard, Jeanette H. Ashina, Messoud Thyssen, Jacob P. Egeberg, Alexander |
author_facet | Wienholtz, Nita K. F. Christensen, Casper E. Zhang, Ditte G. Rechnagel, Anne-Sofie A. Byrnel, Helene V. S. Haugaard, Jeanette H. Ashina, Messoud Thyssen, Jacob P. Egeberg, Alexander |
author_sort | Wienholtz, Nita K. F. |
collection | PubMed |
description | BACKGROUND: An overlap between the skin disease rosacea and the headache disease migraine has been established; however, the magnitude of this overlap and the distribution between subtypes/phenotypes remains unclear. OBJECTIVE: The aim was to determine the magnitude of the overlap between rosacea and migraine, and to determine which subtypes/phenotypes were present in patients with concomitant rosacea and migraine. METHODS: In this cross-sectional study, 604 patients with a diagnosis of either rosacea or migraine were phenotyped through a face-to-face interview with clinical examination, to determine prevalence and phenotype of rosacea, and prevalence and subtype of migraine. RESULTS: We found a prevalence of migraine of 54% in patients with rosacea, and a prevalence of rosacea of 65% in patients with migraine. Concomitant migraine was significantly associated with the rosacea features flushing (odds ratio = 2.6, 95% confidence interval = 1.4–4.7, p = 0.002), ocular symptoms (odds ratio = 2.4, 95% confidence interval = 1.5–3.9, p < 0.001), and burning (odds ratio = 2.1, 95% confidence interval = 1.3–3.4, p = 0.002), whereas papules/pustules were inversely related with concomitant migraine (odds ratio = 0.5, 95% confidence interval = 0.3–0.8, p = 0.006). No association was found between concomitant migraine and centrofacial erythema, rhinophyma, telangiectasia, edema, or dryness. Concomitant rosacea was not associated with any specific migraine subtype in patients with migraine. CONCLUSION: This study highlights a substantial overlap between rosacea and migraine, particularly in patients with certain rosacea features. Individuals with rosacea should be asked about concomitant migraine, and comorbidities should be considered when choosing between treatments. |
format | Online Article Text |
id | pubmed-9635264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96352642022-11-05 Clinical characteristics of combined rosacea and migraine Wienholtz, Nita K. F. Christensen, Casper E. Zhang, Ditte G. Rechnagel, Anne-Sofie A. Byrnel, Helene V. S. Haugaard, Jeanette H. Ashina, Messoud Thyssen, Jacob P. Egeberg, Alexander Front Med (Lausanne) Medicine BACKGROUND: An overlap between the skin disease rosacea and the headache disease migraine has been established; however, the magnitude of this overlap and the distribution between subtypes/phenotypes remains unclear. OBJECTIVE: The aim was to determine the magnitude of the overlap between rosacea and migraine, and to determine which subtypes/phenotypes were present in patients with concomitant rosacea and migraine. METHODS: In this cross-sectional study, 604 patients with a diagnosis of either rosacea or migraine were phenotyped through a face-to-face interview with clinical examination, to determine prevalence and phenotype of rosacea, and prevalence and subtype of migraine. RESULTS: We found a prevalence of migraine of 54% in patients with rosacea, and a prevalence of rosacea of 65% in patients with migraine. Concomitant migraine was significantly associated with the rosacea features flushing (odds ratio = 2.6, 95% confidence interval = 1.4–4.7, p = 0.002), ocular symptoms (odds ratio = 2.4, 95% confidence interval = 1.5–3.9, p < 0.001), and burning (odds ratio = 2.1, 95% confidence interval = 1.3–3.4, p = 0.002), whereas papules/pustules were inversely related with concomitant migraine (odds ratio = 0.5, 95% confidence interval = 0.3–0.8, p = 0.006). No association was found between concomitant migraine and centrofacial erythema, rhinophyma, telangiectasia, edema, or dryness. Concomitant rosacea was not associated with any specific migraine subtype in patients with migraine. CONCLUSION: This study highlights a substantial overlap between rosacea and migraine, particularly in patients with certain rosacea features. Individuals with rosacea should be asked about concomitant migraine, and comorbidities should be considered when choosing between treatments. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9635264/ /pubmed/36341245 http://dx.doi.org/10.3389/fmed.2022.1026447 Text en Copyright © 2022 Wienholtz, Christensen, Zhang, Rechnagel, Byrnel, Haugaard, Ashina, Thyssen and Egeberg. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Wienholtz, Nita K. F. Christensen, Casper E. Zhang, Ditte G. Rechnagel, Anne-Sofie A. Byrnel, Helene V. S. Haugaard, Jeanette H. Ashina, Messoud Thyssen, Jacob P. Egeberg, Alexander Clinical characteristics of combined rosacea and migraine |
title | Clinical characteristics of combined rosacea and migraine |
title_full | Clinical characteristics of combined rosacea and migraine |
title_fullStr | Clinical characteristics of combined rosacea and migraine |
title_full_unstemmed | Clinical characteristics of combined rosacea and migraine |
title_short | Clinical characteristics of combined rosacea and migraine |
title_sort | clinical characteristics of combined rosacea and migraine |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635264/ https://www.ncbi.nlm.nih.gov/pubmed/36341245 http://dx.doi.org/10.3389/fmed.2022.1026447 |
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