Stimuli-responsive transdermal microneedle patches

Microneedle (MN) patches consisting of miniature needles have emerged as a promising tool to perforate the stratum corneum and translocate biomolecules into the dermis in a minimally invasive manner. Stimuli-responsive MN patches represent emerging drug delivery systems that release cargos on-demand...

Descripción completa

Detalles Bibliográficos
Autores principales: Makvandi, Pooyan, Jamaledin, Rezvan, Chen, Guojun, Baghbantaraghdari, Zahra, Zare, Ehsan Nazarzadeh, Di Natale, Concetta, Onesto, Valentina, Vecchione, Raffaele, Lee, Jesse, Tay, Franklin R., Netti, Paolo, Mattoli, Virgilio, Jaklenec, Ana, Gu, Zhen, Langer, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635273/
https://www.ncbi.nlm.nih.gov/pubmed/36338772
http://dx.doi.org/10.1016/j.mattod.2021.03.012
Descripción
Sumario:Microneedle (MN) patches consisting of miniature needles have emerged as a promising tool to perforate the stratum corneum and translocate biomolecules into the dermis in a minimally invasive manner. Stimuli-responsive MN patches represent emerging drug delivery systems that release cargos on-demand as a response to internal or external triggers. In this review, a variety of stimuli-responsive MN patches for controlled drug release are introduced, covering the mechanisms of action toward different indications. Future opportunities and challenges with respect to clinical translation are also discussed.

Ejemplares similares