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Trisomy 21 increases microtubules and disrupts centriolar satellite localization

Trisomy 21, the source of Down syndrome, causes a 0.5-fold protein increase of the chromosome 21-resident gene Pericentrin (PCNT) and reduces primary cilia formation and signaling. We investigate how PCNT imbalances disrupt cilia. Using isogenic RPE-1 cells with increased chromosome 21 dosage, we fi...

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Detalles Bibliográficos
Autores principales:	McCurdy, Bailey L., Jewett, Cayla E., Stemm-Wolf, Alexander J., Duc, Huy Nguyen, Joshi, Molishree, Espinosa, Joaquin M., Prekeris, Rytis, Pearson, Chad G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2022
Materias:	Brief Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635274/ https://www.ncbi.nlm.nih.gov/pubmed/35476505 http://dx.doi.org/10.1091/mbc.E21-10-0517-T

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