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Effects of Alexander disease–associated mutations on the assembly and organization of GFAP intermediate filaments

Alexander disease is a primary genetic disorder of astrocytes caused by dominant mutations in the gene encoding glial fibrillary acidic protein (GFAP). How single-amino-acid changes can lead to cytoskeletal catastrophe and brain degeneration remains poorly understood. In this study, we have analyzed...

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Detalles Bibliográficos
Autores principales:	Yang, Ai-Wen, Lin, Ni-Hsuan, Yeh, Ting-Hung, Snider, Natasha, Perng, Ming-Der
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635275/ https://www.ncbi.nlm.nih.gov/pubmed/35511821 http://dx.doi.org/10.1091/mbc.E22-01-0013

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