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Sperm DNA Fragmentation in Reproductive Medicine: A Review

Approximately 15% of the world's couples suffer from infertility during their reproductive period of which the male factor is responsible for 50% of cases. Male factor infertility is multifactorial in origin, and sperm DNA fragmentation (SDF) has also been linked to male infertility including i...

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Autores principales: Alahmar, Ahmed T., Singh, Rajender, Palani, Ayad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635374/
https://www.ncbi.nlm.nih.gov/pubmed/36341018
http://dx.doi.org/10.4103/jhrs.jhrs_82_22
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author Alahmar, Ahmed T.
Singh, Rajender
Palani, Ayad
author_facet Alahmar, Ahmed T.
Singh, Rajender
Palani, Ayad
author_sort Alahmar, Ahmed T.
collection PubMed
description Approximately 15% of the world's couples suffer from infertility during their reproductive period of which the male factor is responsible for 50% of cases. Male factor infertility is multifactorial in origin, and sperm DNA fragmentation (SDF) has also been linked to male infertility including idiopathic male infertility. Some degree of controlled DNA nicking is essential for adequate DNA compaction, but excessive SDF is usually associated with reduced male fertility potential, reduced fertilisation, poor embryo quality, recurrent pregnancy loss and poor assisted reproductive techniques (ARTs) outcomes. Although semen analysis remains the gold standard for diagnosis of male factor infertility worldwide, its limitations motivated the search and the development of complementary tests of sperm function and integrity. SDF assay is an emerging diagnostic tool in infertile men, and several indications for SDF testing in infertile couples have also been proposed. The use of SDF in routine male infertility assessment is, however, still controversial. Furthermore, both direct and indirect SDF tests are now available. Hence, the present review was conducted to summarise the recent evidence of SDF, underlying mechanisms, clinical indications, diagnostic tests, as well as the role of SDF in male factor infertility, pregnancy and ART outcomes.
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spelling pubmed-96353742022-11-05 Sperm DNA Fragmentation in Reproductive Medicine: A Review Alahmar, Ahmed T. Singh, Rajender Palani, Ayad J Hum Reprod Sci Review Article Approximately 15% of the world's couples suffer from infertility during their reproductive period of which the male factor is responsible for 50% of cases. Male factor infertility is multifactorial in origin, and sperm DNA fragmentation (SDF) has also been linked to male infertility including idiopathic male infertility. Some degree of controlled DNA nicking is essential for adequate DNA compaction, but excessive SDF is usually associated with reduced male fertility potential, reduced fertilisation, poor embryo quality, recurrent pregnancy loss and poor assisted reproductive techniques (ARTs) outcomes. Although semen analysis remains the gold standard for diagnosis of male factor infertility worldwide, its limitations motivated the search and the development of complementary tests of sperm function and integrity. SDF assay is an emerging diagnostic tool in infertile men, and several indications for SDF testing in infertile couples have also been proposed. The use of SDF in routine male infertility assessment is, however, still controversial. Furthermore, both direct and indirect SDF tests are now available. Hence, the present review was conducted to summarise the recent evidence of SDF, underlying mechanisms, clinical indications, diagnostic tests, as well as the role of SDF in male factor infertility, pregnancy and ART outcomes. Wolters Kluwer - Medknow 2022 2022-09-30 /pmc/articles/PMC9635374/ /pubmed/36341018 http://dx.doi.org/10.4103/jhrs.jhrs_82_22 Text en Copyright: © 2022 Journal of Human Reproductive Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Alahmar, Ahmed T.
Singh, Rajender
Palani, Ayad
Sperm DNA Fragmentation in Reproductive Medicine: A Review
title Sperm DNA Fragmentation in Reproductive Medicine: A Review
title_full Sperm DNA Fragmentation in Reproductive Medicine: A Review
title_fullStr Sperm DNA Fragmentation in Reproductive Medicine: A Review
title_full_unstemmed Sperm DNA Fragmentation in Reproductive Medicine: A Review
title_short Sperm DNA Fragmentation in Reproductive Medicine: A Review
title_sort sperm dna fragmentation in reproductive medicine: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635374/
https://www.ncbi.nlm.nih.gov/pubmed/36341018
http://dx.doi.org/10.4103/jhrs.jhrs_82_22
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