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Effect of Long-Term Embryo Cryopreservation on Subsequent Frozen Embryo Transfer Outcomes: A Retrospective Cohort Study
BACKGROUND: The duration of cryopreservation of embryos and its effect on the subsequent pregnancy outcomes, when they have been frozen for a longer duration remains a matter of concern. There is a continuous debate among studies comparing different durations of embryo cryopreservation as the result...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635375/ https://www.ncbi.nlm.nih.gov/pubmed/36341019 http://dx.doi.org/10.4103/jhrs.jhrs_83_22 |
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author | Reddy, Nallamilli Sujatha Parimala, Chinta Karuppusami, Reka Mangalraj, Ann Margret Kunjummen, Aleyamma Thaiparambil |
author_facet | Reddy, Nallamilli Sujatha Parimala, Chinta Karuppusami, Reka Mangalraj, Ann Margret Kunjummen, Aleyamma Thaiparambil |
author_sort | Reddy, Nallamilli Sujatha |
collection | PubMed |
description | BACKGROUND: The duration of cryopreservation of embryos and its effect on the subsequent pregnancy outcomes, when they have been frozen for a longer duration remains a matter of concern. There is a continuous debate among studies comparing different durations of embryo cryopreservation as the results are contradictory. AIMS: This study aims to find out if long-term cryopreservation of embryos has any effect on pregnancy and perinatal outcomes. SETTINGS AND DESIGN: :Retrospective cohort study was conducted in the department of reproductive medicine and surgery in a university-level teaching hospital. MATERIALS AND METHODS: The study included women who underwent frozen embryo transfer (FET) from autologous in vitro fertilisation between January 2012 and December 2020 with the duration of cryopreservation of more than 5 years as one group and 3–5 years as another group. Pregnancy and perinatal outcomes were analysed. STATISTICAL ANALYSIS USED: Regression analysis was performed using logistic regression by entering clinically important variables associated with pregnancy outcome, and the results were expressed as odds ratio with a 95% confidence interval (CI). All statistical analysis was performed with SPSS (version 21.0, IBM, USA). RESULTS: A total of 1680 FET cycles were carried out during the study period. Among these, 75 cycles with a duration of 3–5 years and 20 cycles with a duration of more than 5 years were included. Live birth rate (LBR) was 40.8% in the 3–5 years group and 35% in the more than 5 years group. After adjusting for important confounders, the LBR has no significant association in the more than 5 years group (adjusted odds ratio 1.07; 95% CI 0.34–3.32; P = 0.913) compared to the 3–5 years group. CONCLUSION: The duration of cryopreservation of embryos has no statistically significant effect on the pregnancy and perinatal outcomes. |
format | Online Article Text |
id | pubmed-9635375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-96353752022-11-05 Effect of Long-Term Embryo Cryopreservation on Subsequent Frozen Embryo Transfer Outcomes: A Retrospective Cohort Study Reddy, Nallamilli Sujatha Parimala, Chinta Karuppusami, Reka Mangalraj, Ann Margret Kunjummen, Aleyamma Thaiparambil J Hum Reprod Sci Original Article BACKGROUND: The duration of cryopreservation of embryos and its effect on the subsequent pregnancy outcomes, when they have been frozen for a longer duration remains a matter of concern. There is a continuous debate among studies comparing different durations of embryo cryopreservation as the results are contradictory. AIMS: This study aims to find out if long-term cryopreservation of embryos has any effect on pregnancy and perinatal outcomes. SETTINGS AND DESIGN: :Retrospective cohort study was conducted in the department of reproductive medicine and surgery in a university-level teaching hospital. MATERIALS AND METHODS: The study included women who underwent frozen embryo transfer (FET) from autologous in vitro fertilisation between January 2012 and December 2020 with the duration of cryopreservation of more than 5 years as one group and 3–5 years as another group. Pregnancy and perinatal outcomes were analysed. STATISTICAL ANALYSIS USED: Regression analysis was performed using logistic regression by entering clinically important variables associated with pregnancy outcome, and the results were expressed as odds ratio with a 95% confidence interval (CI). All statistical analysis was performed with SPSS (version 21.0, IBM, USA). RESULTS: A total of 1680 FET cycles were carried out during the study period. Among these, 75 cycles with a duration of 3–5 years and 20 cycles with a duration of more than 5 years were included. Live birth rate (LBR) was 40.8% in the 3–5 years group and 35% in the more than 5 years group. After adjusting for important confounders, the LBR has no significant association in the more than 5 years group (adjusted odds ratio 1.07; 95% CI 0.34–3.32; P = 0.913) compared to the 3–5 years group. CONCLUSION: The duration of cryopreservation of embryos has no statistically significant effect on the pregnancy and perinatal outcomes. Wolters Kluwer - Medknow 2022 2022-09-30 /pmc/articles/PMC9635375/ /pubmed/36341019 http://dx.doi.org/10.4103/jhrs.jhrs_83_22 Text en Copyright: © 2022 Journal of Human Reproductive Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Reddy, Nallamilli Sujatha Parimala, Chinta Karuppusami, Reka Mangalraj, Ann Margret Kunjummen, Aleyamma Thaiparambil Effect of Long-Term Embryo Cryopreservation on Subsequent Frozen Embryo Transfer Outcomes: A Retrospective Cohort Study |
title | Effect of Long-Term Embryo Cryopreservation on Subsequent Frozen Embryo Transfer Outcomes: A Retrospective Cohort Study |
title_full | Effect of Long-Term Embryo Cryopreservation on Subsequent Frozen Embryo Transfer Outcomes: A Retrospective Cohort Study |
title_fullStr | Effect of Long-Term Embryo Cryopreservation on Subsequent Frozen Embryo Transfer Outcomes: A Retrospective Cohort Study |
title_full_unstemmed | Effect of Long-Term Embryo Cryopreservation on Subsequent Frozen Embryo Transfer Outcomes: A Retrospective Cohort Study |
title_short | Effect of Long-Term Embryo Cryopreservation on Subsequent Frozen Embryo Transfer Outcomes: A Retrospective Cohort Study |
title_sort | effect of long-term embryo cryopreservation on subsequent frozen embryo transfer outcomes: a retrospective cohort study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635375/ https://www.ncbi.nlm.nih.gov/pubmed/36341019 http://dx.doi.org/10.4103/jhrs.jhrs_83_22 |
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