Mathematical Modeling and Mutational Analysis Reveal Optimal Therapy to Prevent Malignant Transformation in Grade II IDH-Mutant Gliomas

Isocitrate dehydrogenase-mutant low-grade gliomas (IDHmut-LGG) grow slowly but frequently undergo malignant transformation, which eventually leads to premature death. Chemotherapy and radiotherapy treatments prolong survival, but can also induce genetic (or epigenetic) alterations involved in transf...

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Detalles Bibliográficos
Autores principales: Aoki, Kosuke, Suzuki, Hiromichi, Yamamoto, Takashi, Yamamoto, Kimiyo N., Maeda, Sachi, Okuno, Yusuke, Ranjit, Melissa, Motomura, Kazuya, Ohka, Fumiharu, Tanahashi, Kuniaki, Hirano, Masaki, Nishikawa, Tomohide, Shimizu, Hiroyuki, Kitano, Yotaro, Yamaguchi, Junya, Yamazaki, Shintaro, Nakamura, Hideo, Takahashi, Masamichi, Narita, Yoshitaka, Nakada, Mitsutoshi, Deguchi, Shoichi, Mizoguchi, Masahiro, Momii, Yasutomo, Muragaki, Yoshihiro, Abe, Tatsuya, Akimoto, Jiro, Wakabayashi, Toshihiko, Saito, Ryuta, Ogawa, Seishi, Haeno, Hiroshi, Natsume, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Convergence and Technologies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635454/
https://www.ncbi.nlm.nih.gov/pubmed/34333454
http://dx.doi.org/10.1158/0008-5472.CAN-21-0985

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