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Design, synthesis, and biological evaluation of novel ciprofloxacin derivatives as potential anticancer agents targeting topoisomerase II enzyme

A series of novel ciprofloxacin (CP) derivatives substituted at the N-4 position with biologically active moieties were designed and synthesised. 14 compounds were 1.02- to 8.66-fold more potent than doxorubicin against T-24 cancer cells. Ten compounds were 1.2- to 7.1-fold more potent than doxorubi...

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Detalles Bibliográficos
Autores principales:	Swedan, Hadeer K., Kassab, Asmaa E., Gedawy, Ehab M., Elmeligie, Salwa E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635472/ https://www.ncbi.nlm.nih.gov/pubmed/36305290 http://dx.doi.org/10.1080/14756366.2022.2136172

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