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LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway

Radiation resistance poses a major clinical challenge in breast cancer (BC) treatment, but little is known about how long noncoding RNA (lncRNA) may regulate this phenomenon. Here, we reported that DUXAP8 was highly expressed in radioresistant BC tissues, and high expression of DUXAP8 was associated...

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Autores principales: Lei, Changjiang, Li, Shaoting, Fan, Ying, Hua, Li, Pan, Qingyun, Li, Yuan, Long, Zhixiong, Yang, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635553/
https://www.ncbi.nlm.nih.gov/pubmed/36329030
http://dx.doi.org/10.1080/15384047.2022.2132008
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author Lei, Changjiang
Li, Shaoting
Fan, Ying
Hua, Li
Pan, Qingyun
Li, Yuan
Long, Zhixiong
Yang, Rui
author_facet Lei, Changjiang
Li, Shaoting
Fan, Ying
Hua, Li
Pan, Qingyun
Li, Yuan
Long, Zhixiong
Yang, Rui
author_sort Lei, Changjiang
collection PubMed
description Radiation resistance poses a major clinical challenge in breast cancer (BC) treatment, but little is known about how long noncoding RNA (lncRNA) may regulate this phenomenon. Here, we reported that DUXAP8 was highly expressed in radioresistant BC tissues, and high expression of DUXAP8 was associated with poor prognosis. We found that the overexpression of DUXAP8 promoted radioresistance, while the knockdown of DUXAP8 expression increased radiosensitivity. Further studies revealed that DUXAP8 enhanced the radioresistance of BC cells by activating the PI3K/AKT/mTOR pathway and by repressing the expression of E-cadherin and RHOB through interaction with EZH2. Together, our work demonstrates that the overexpression of DUXAP8 promotes the resistance of BC cells toward radiation through modulating PI3K/AKT/mTOR pathway and EZH2-E-cadherin/RHOB axis. Targeting DUXAP8 may serve as a potential strategy to overcome radioresistance in BC treatment.
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spelling pubmed-96355532022-11-05 LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway Lei, Changjiang Li, Shaoting Fan, Ying Hua, Li Pan, Qingyun Li, Yuan Long, Zhixiong Yang, Rui Cancer Biol Ther Research Paper Radiation resistance poses a major clinical challenge in breast cancer (BC) treatment, but little is known about how long noncoding RNA (lncRNA) may regulate this phenomenon. Here, we reported that DUXAP8 was highly expressed in radioresistant BC tissues, and high expression of DUXAP8 was associated with poor prognosis. We found that the overexpression of DUXAP8 promoted radioresistance, while the knockdown of DUXAP8 expression increased radiosensitivity. Further studies revealed that DUXAP8 enhanced the radioresistance of BC cells by activating the PI3K/AKT/mTOR pathway and by repressing the expression of E-cadherin and RHOB through interaction with EZH2. Together, our work demonstrates that the overexpression of DUXAP8 promotes the resistance of BC cells toward radiation through modulating PI3K/AKT/mTOR pathway and EZH2-E-cadherin/RHOB axis. Targeting DUXAP8 may serve as a potential strategy to overcome radioresistance in BC treatment. Taylor & Francis 2022-11-03 /pmc/articles/PMC9635553/ /pubmed/36329030 http://dx.doi.org/10.1080/15384047.2022.2132008 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Lei, Changjiang
Li, Shaoting
Fan, Ying
Hua, Li
Pan, Qingyun
Li, Yuan
Long, Zhixiong
Yang, Rui
LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway
title LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway
title_full LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway
title_fullStr LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway
title_full_unstemmed LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway
title_short LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway
title_sort lncrna duxap8 induces breast cancer radioresistance by modulating the pi3k/akt/mtor pathway and the ezh2-e-cadherin/rhob pathway
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635553/
https://www.ncbi.nlm.nih.gov/pubmed/36329030
http://dx.doi.org/10.1080/15384047.2022.2132008
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