Cardiac Contractility Modulation: A Technical Review

Therapeutic options for the management of systolic congestive heart failure involving newer implantable device technologies that were not previously available now exist. Cardiac contractility modulation (CCM) has been shown to benefit patients with class III systolic heart failure with an ejection fraction of 25%–45% not indicated for biventricular pacing. Despite the increased use of CCM, there is a significant knowledge deficit in the general electrophysiology community regarding its clinical management. This significantly relates to the different functional characteristics of CCM compared to those encountered in traditional cardiac rhythm management devices. Improved evaluation and troubleshooting of CCM for therapeutic effect will benefit from advanced education. The goal of this review is to present pertinent technical aspects relating to CCM therapy management in a simplified fashion, all the while providing a clinical context to facilitate greater expertise.