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Comparing maternal outcomes in spontaneous singleton pregnancies versus in vitro fertilization conception: Single-center 10-year cohort study
OBJECTIVE: A successful assisted reproductive technique (ART) cycle is not flawless, and several studies have reported high incidences of maternal complications, but the association is inconclusive. In addition, the racial and ethnic effects of the Asian population undergoing ART on maternal outcome...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Brazilian Society of Assisted Reproduction
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635605/ https://www.ncbi.nlm.nih.gov/pubmed/35822701 http://dx.doi.org/10.5935/1518-0557.20220002 |
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author | Singh, Neeta Malhotra, Neena Mahey, Reeta Saini, Monika Patel, Garima Sethi, Ankita |
author_facet | Singh, Neeta Malhotra, Neena Mahey, Reeta Saini, Monika Patel, Garima Sethi, Ankita |
author_sort | Singh, Neeta |
collection | PubMed |
description | OBJECTIVE: A successful assisted reproductive technique (ART) cycle is not flawless, and several studies have reported high incidences of maternal complications, but the association is inconclusive. In addition, the racial and ethnic effects of the Asian population undergoing ART on maternal outcomes is not well studied. This study attempts to compare various maternal outcome parameters ART and spontaneously conceived singleton pregnancies from a single high volume tertiary care centre. METHODS: A retrospective cohort study from a single tertiary infertility center was conducted from January 2011 to September 2020. The study included 1125 IVF conceived singletons (AP group) and 7193 spontaneous conceived singletons (SP group). The groups were compared using the Pearson Chi-square test and the adjusted odds ratio calculated using multivariate analysis. RESULTS: Maternal outcomes like gestational hypertension, pre-eclampsia, gestational diabetes (GDM), oligohydramnios, chorioamnionitis, operative, and instrumental delivery were significantly different in the two groups (p<0.05). The AP group had a significantly increased risk of GDM (aOR 1.093; 95% CI 1.076-1.110) and pregnancy-induced hypertension (PIH) (aOR 1.577; 95% CI 1.288-1.930) as compared to the SP group. IVF significantly increases the risk of abruption by 2 times (p=0.028), and independently increases the risk of caesarean section by 3.1-fold (p<0.001). But overall the IVF is the protective factor for oligohydramnios (p=0.024). CONCLUSIONS: ART increases the likelihood of pregnancy-related maternal complications, such as PIH, GDM, abruption, chorioamnionitis, and an increased rate of caesarean delivery. Thus, all patients undergoing ART procedures should receive pre-conceptional counselling regarding the associated obstetric risks and consider ART pregnancy as a high-risk pregnancy. |
format | Online Article Text |
id | pubmed-9635605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Brazilian Society of Assisted Reproduction |
record_format | MEDLINE/PubMed |
spelling | pubmed-96356052022-11-07 Comparing maternal outcomes in spontaneous singleton pregnancies versus in vitro fertilization conception: Single-center 10-year cohort study Singh, Neeta Malhotra, Neena Mahey, Reeta Saini, Monika Patel, Garima Sethi, Ankita JBRA Assist Reprod Original Article OBJECTIVE: A successful assisted reproductive technique (ART) cycle is not flawless, and several studies have reported high incidences of maternal complications, but the association is inconclusive. In addition, the racial and ethnic effects of the Asian population undergoing ART on maternal outcomes is not well studied. This study attempts to compare various maternal outcome parameters ART and spontaneously conceived singleton pregnancies from a single high volume tertiary care centre. METHODS: A retrospective cohort study from a single tertiary infertility center was conducted from January 2011 to September 2020. The study included 1125 IVF conceived singletons (AP group) and 7193 spontaneous conceived singletons (SP group). The groups were compared using the Pearson Chi-square test and the adjusted odds ratio calculated using multivariate analysis. RESULTS: Maternal outcomes like gestational hypertension, pre-eclampsia, gestational diabetes (GDM), oligohydramnios, chorioamnionitis, operative, and instrumental delivery were significantly different in the two groups (p<0.05). The AP group had a significantly increased risk of GDM (aOR 1.093; 95% CI 1.076-1.110) and pregnancy-induced hypertension (PIH) (aOR 1.577; 95% CI 1.288-1.930) as compared to the SP group. IVF significantly increases the risk of abruption by 2 times (p=0.028), and independently increases the risk of caesarean section by 3.1-fold (p<0.001). But overall the IVF is the protective factor for oligohydramnios (p=0.024). CONCLUSIONS: ART increases the likelihood of pregnancy-related maternal complications, such as PIH, GDM, abruption, chorioamnionitis, and an increased rate of caesarean delivery. Thus, all patients undergoing ART procedures should receive pre-conceptional counselling regarding the associated obstetric risks and consider ART pregnancy as a high-risk pregnancy. Brazilian Society of Assisted Reproduction 2022 /pmc/articles/PMC9635605/ /pubmed/35822701 http://dx.doi.org/10.5935/1518-0557.20220002 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Singh, Neeta Malhotra, Neena Mahey, Reeta Saini, Monika Patel, Garima Sethi, Ankita Comparing maternal outcomes in spontaneous singleton pregnancies versus in vitro fertilization conception: Single-center 10-year cohort study |
title | Comparing maternal outcomes in spontaneous singleton pregnancies
versus in vitro fertilization conception: Single-center 10-year
cohort study |
title_full | Comparing maternal outcomes in spontaneous singleton pregnancies
versus in vitro fertilization conception: Single-center 10-year
cohort study |
title_fullStr | Comparing maternal outcomes in spontaneous singleton pregnancies
versus in vitro fertilization conception: Single-center 10-year
cohort study |
title_full_unstemmed | Comparing maternal outcomes in spontaneous singleton pregnancies
versus in vitro fertilization conception: Single-center 10-year
cohort study |
title_short | Comparing maternal outcomes in spontaneous singleton pregnancies
versus in vitro fertilization conception: Single-center 10-year
cohort study |
title_sort | comparing maternal outcomes in spontaneous singleton pregnancies
versus in vitro fertilization conception: single-center 10-year
cohort study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635605/ https://www.ncbi.nlm.nih.gov/pubmed/35822701 http://dx.doi.org/10.5935/1518-0557.20220002 |
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