N-Methyl-(2S, 4R)-trans-4-hydroxy-L-proline, the major bioactive compound from Sideroxylon obtusifolium, attenuates pilocarpine-induced injury in cultured astrocytes

Glial cells have been implicated in temporal lobe epilepsy in humans and in its models. Astrocytes are lost in several brain regions after acute seizures induced by pilocarpine and may suffer hyperplasia at subsequent time points. This study investigated the effect of N-methyl-(2S,4R)-trans-4-hydrox...

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Detalles Bibliográficos
Autores principales: Aquino, P.E.A., de Siqueira, E.A., Paes, L.C.F., Magalhães, E.P., Barbosa, T.M., de Carvalho, M.A.J., Azul, F.V.C. Serra, Lustosa, I. Rosal, Mottin, M., Sampaio, T.L., Martins, A.M.C., Silveira, E.R., Viana, G.S.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635815/
https://www.ncbi.nlm.nih.gov/pubmed/36350974
http://dx.doi.org/10.1590/1414-431X2022e12381

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