Tissue-engineered grafts exploit axon-facilitated axon regeneration and pathway protection to enable recovery after 5-cm nerve defects in pigs

Functional restoration following major peripheral nerve injury (PNI) is challenging, given slow axon growth rates and eventual regenerative pathway degradation in the absence of axons. We are developing tissue-engineered nerve grafts (TENGs) to simultaneously “bridge” missing nerve segments and “bab...

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Detalles Bibliográficos
Autores principales: Smith, Douglas H., Burrell, Justin C., Browne, Kevin D., Katiyar, Kritika S., Ezra, Mindy I., Dutton, John L., Morand, Joseph P., Struzyna, Laura A., Laimo, Franco A., Chen, H. Isaac, Wolf, John A., Kaplan, Hilton M., Rosen, Joseph M., Ledebur, Harry C., Zager, Eric L., Ali, Zarina S., Cullen, D. Kacy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635828/
https://www.ncbi.nlm.nih.gov/pubmed/36332027
http://dx.doi.org/10.1126/sciadv.abm3291

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