Insights into the evolution of enzymatic specificity and catalysis: From Asgard archaea to human adenylate kinases

Enzymatic catalysis is critically dependent on selectivity, active site architecture, and dynamics. To contribute insights into the interplay of these properties, we established an approach with NMR, crystallography, and MD simulations focused on the ubiquitous phosphotransferase adenylate kinase (A...

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Detalles Bibliográficos
Autores principales: Verma, Apoorv, Åberg-Zingmark, Emma, Sparrman, Tobias, Mushtaq, Ameeq Ul, Rogne, Per, Grundström, Christin, Berntsson, Ronnie, Sauer, Uwe H., Backman, Lars, Nam, Kwangho, Sauer-Eriksson, Elisabeth, Wolf-Watz, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635829/
https://www.ncbi.nlm.nih.gov/pubmed/36332013
http://dx.doi.org/10.1126/sciadv.abm4089

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