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Early developmental plasticity enables the induction of an intermediate extraembryonic cell state
Two fundamental elements of pre-implantation embryogenesis are cells’ intrinsic self-organization program and their developmental plasticity, which allows embryos to compensate for alterations in cell position and number; yet, these elements are still poorly understood. To be able to decipher these...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Association for the Advancement of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635831/ https://www.ncbi.nlm.nih.gov/pubmed/36332016 http://dx.doi.org/10.1126/sciadv.abl9583 |
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author | Sathyanarayanan, Anusha Ing-Simmons, Elizabeth Chen, Rui Jeong, Hyun-Woo Ozguldez, Hatice O. Fan, Rui Duethorn, Binyamin Kim, Kee-Pyo Kim, Yung Su Stehling, Martin Brinkmann, Heike Schöler, Hans R. Adams, Ralf H. Vaquerizas, Juan M. Bedzhov, Ivan |
author_facet | Sathyanarayanan, Anusha Ing-Simmons, Elizabeth Chen, Rui Jeong, Hyun-Woo Ozguldez, Hatice O. Fan, Rui Duethorn, Binyamin Kim, Kee-Pyo Kim, Yung Su Stehling, Martin Brinkmann, Heike Schöler, Hans R. Adams, Ralf H. Vaquerizas, Juan M. Bedzhov, Ivan |
author_sort | Sathyanarayanan, Anusha |
collection | PubMed |
description | Two fundamental elements of pre-implantation embryogenesis are cells’ intrinsic self-organization program and their developmental plasticity, which allows embryos to compensate for alterations in cell position and number; yet, these elements are still poorly understood. To be able to decipher these features, we established culture conditions that enable the two fates of blastocysts’ extraembryonic lineages—the primitive endoderm and the trophectoderm—to coexist. This plasticity emerges following the mechanisms of the first lineage segregation in the mouse embryo, and it manifests as an extended potential for extraembryonic chimerism during the pre-implantation embryogenesis. Moreover, this shared state enables robust assembly into higher-order blastocyst-like structures, thus combining both the cell fate plasticity and self-organization features of the early extraembryonic lineages. |
format | Online Article Text |
id | pubmed-9635831 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-96358312022-11-18 Early developmental plasticity enables the induction of an intermediate extraembryonic cell state Sathyanarayanan, Anusha Ing-Simmons, Elizabeth Chen, Rui Jeong, Hyun-Woo Ozguldez, Hatice O. Fan, Rui Duethorn, Binyamin Kim, Kee-Pyo Kim, Yung Su Stehling, Martin Brinkmann, Heike Schöler, Hans R. Adams, Ralf H. Vaquerizas, Juan M. Bedzhov, Ivan Sci Adv Biomedicine and Life Sciences Two fundamental elements of pre-implantation embryogenesis are cells’ intrinsic self-organization program and their developmental plasticity, which allows embryos to compensate for alterations in cell position and number; yet, these elements are still poorly understood. To be able to decipher these features, we established culture conditions that enable the two fates of blastocysts’ extraembryonic lineages—the primitive endoderm and the trophectoderm—to coexist. This plasticity emerges following the mechanisms of the first lineage segregation in the mouse embryo, and it manifests as an extended potential for extraembryonic chimerism during the pre-implantation embryogenesis. Moreover, this shared state enables robust assembly into higher-order blastocyst-like structures, thus combining both the cell fate plasticity and self-organization features of the early extraembryonic lineages. American Association for the Advancement of Science 2022-11-04 /pmc/articles/PMC9635831/ /pubmed/36332016 http://dx.doi.org/10.1126/sciadv.abl9583 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Biomedicine and Life Sciences Sathyanarayanan, Anusha Ing-Simmons, Elizabeth Chen, Rui Jeong, Hyun-Woo Ozguldez, Hatice O. Fan, Rui Duethorn, Binyamin Kim, Kee-Pyo Kim, Yung Su Stehling, Martin Brinkmann, Heike Schöler, Hans R. Adams, Ralf H. Vaquerizas, Juan M. Bedzhov, Ivan Early developmental plasticity enables the induction of an intermediate extraembryonic cell state |
title | Early developmental plasticity enables the induction of an intermediate extraembryonic cell state |
title_full | Early developmental plasticity enables the induction of an intermediate extraembryonic cell state |
title_fullStr | Early developmental plasticity enables the induction of an intermediate extraembryonic cell state |
title_full_unstemmed | Early developmental plasticity enables the induction of an intermediate extraembryonic cell state |
title_short | Early developmental plasticity enables the induction of an intermediate extraembryonic cell state |
title_sort | early developmental plasticity enables the induction of an intermediate extraembryonic cell state |
topic | Biomedicine and Life Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635831/ https://www.ncbi.nlm.nih.gov/pubmed/36332016 http://dx.doi.org/10.1126/sciadv.abl9583 |
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