Cargando…
A Case of Thrombotic Thrombocytopenic Purpura Possibly Induced by Graves’ Disease
Thrombotic thrombocytopenic purpura (TTP) has historically been diagnosed with a pentad of features, i.e., thrombocytopenia, micro-angiopathic hemolytic anemia (MAHA), fever, neurological abnormalities, and kidney failure. Traditionally, TTP cases have been described in healthy adults. However, thei...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635859/ https://www.ncbi.nlm.nih.gov/pubmed/36381849 http://dx.doi.org/10.7759/cureus.29961 |
_version_ | 1784824806317752320 |
---|---|
author | Bains, Shifali Patel, Kriyesha Bath, Taranjit Singh, Pawanpreet Kaur, Ravanjit Patel, Parth Jamali, Momal Ghaffari, Muhammad Abu Zar |
author_facet | Bains, Shifali Patel, Kriyesha Bath, Taranjit Singh, Pawanpreet Kaur, Ravanjit Patel, Parth Jamali, Momal Ghaffari, Muhammad Abu Zar |
author_sort | Bains, Shifali |
collection | PubMed |
description | Thrombotic thrombocytopenic purpura (TTP) has historically been diagnosed with a pentad of features, i.e., thrombocytopenia, micro-angiopathic hemolytic anemia (MAHA), fever, neurological abnormalities, and kidney failure. Traditionally, TTP cases have been described in healthy adults. However, their association with autoimmune diseases is now well documented in the literature. There is limited availability of literature on the association between TTP and Graves' disease (GD). Here, we report a case of an adult female, a known case of Graves’ disease, who has now been diagnosed with an acquired case of TTP. The presence of MAHA associated with thrombocytopenia was considered a clinical diagnosis of TTP and the patient immediately underwent plasma exchange (PEX), which led to the resolution of complaints. Hyperthyroidism cases should be adequately followed up as clinical severity could lead to the emergence of TTP. |
format | Online Article Text |
id | pubmed-9635859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-96358592022-11-14 A Case of Thrombotic Thrombocytopenic Purpura Possibly Induced by Graves’ Disease Bains, Shifali Patel, Kriyesha Bath, Taranjit Singh, Pawanpreet Kaur, Ravanjit Patel, Parth Jamali, Momal Ghaffari, Muhammad Abu Zar Cureus Endocrinology/Diabetes/Metabolism Thrombotic thrombocytopenic purpura (TTP) has historically been diagnosed with a pentad of features, i.e., thrombocytopenia, micro-angiopathic hemolytic anemia (MAHA), fever, neurological abnormalities, and kidney failure. Traditionally, TTP cases have been described in healthy adults. However, their association with autoimmune diseases is now well documented in the literature. There is limited availability of literature on the association between TTP and Graves' disease (GD). Here, we report a case of an adult female, a known case of Graves’ disease, who has now been diagnosed with an acquired case of TTP. The presence of MAHA associated with thrombocytopenia was considered a clinical diagnosis of TTP and the patient immediately underwent plasma exchange (PEX), which led to the resolution of complaints. Hyperthyroidism cases should be adequately followed up as clinical severity could lead to the emergence of TTP. Cureus 2022-10-05 /pmc/articles/PMC9635859/ /pubmed/36381849 http://dx.doi.org/10.7759/cureus.29961 Text en Copyright © 2022, Bains et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Endocrinology/Diabetes/Metabolism Bains, Shifali Patel, Kriyesha Bath, Taranjit Singh, Pawanpreet Kaur, Ravanjit Patel, Parth Jamali, Momal Ghaffari, Muhammad Abu Zar A Case of Thrombotic Thrombocytopenic Purpura Possibly Induced by Graves’ Disease |
title | A Case of Thrombotic Thrombocytopenic Purpura Possibly Induced by Graves’ Disease |
title_full | A Case of Thrombotic Thrombocytopenic Purpura Possibly Induced by Graves’ Disease |
title_fullStr | A Case of Thrombotic Thrombocytopenic Purpura Possibly Induced by Graves’ Disease |
title_full_unstemmed | A Case of Thrombotic Thrombocytopenic Purpura Possibly Induced by Graves’ Disease |
title_short | A Case of Thrombotic Thrombocytopenic Purpura Possibly Induced by Graves’ Disease |
title_sort | case of thrombotic thrombocytopenic purpura possibly induced by graves’ disease |
topic | Endocrinology/Diabetes/Metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635859/ https://www.ncbi.nlm.nih.gov/pubmed/36381849 http://dx.doi.org/10.7759/cureus.29961 |
work_keys_str_mv | AT bainsshifali acaseofthromboticthrombocytopenicpurpurapossiblyinducedbygravesdisease AT patelkriyesha acaseofthromboticthrombocytopenicpurpurapossiblyinducedbygravesdisease AT bathtaranjit acaseofthromboticthrombocytopenicpurpurapossiblyinducedbygravesdisease AT singhpawanpreet acaseofthromboticthrombocytopenicpurpurapossiblyinducedbygravesdisease AT kaurravanjit acaseofthromboticthrombocytopenicpurpurapossiblyinducedbygravesdisease AT patelparth acaseofthromboticthrombocytopenicpurpurapossiblyinducedbygravesdisease AT jamalimomal acaseofthromboticthrombocytopenicpurpurapossiblyinducedbygravesdisease AT ghaffarimuhammadabuzar acaseofthromboticthrombocytopenicpurpurapossiblyinducedbygravesdisease AT bainsshifali caseofthromboticthrombocytopenicpurpurapossiblyinducedbygravesdisease AT patelkriyesha caseofthromboticthrombocytopenicpurpurapossiblyinducedbygravesdisease AT bathtaranjit caseofthromboticthrombocytopenicpurpurapossiblyinducedbygravesdisease AT singhpawanpreet caseofthromboticthrombocytopenicpurpurapossiblyinducedbygravesdisease AT kaurravanjit caseofthromboticthrombocytopenicpurpurapossiblyinducedbygravesdisease AT patelparth caseofthromboticthrombocytopenicpurpurapossiblyinducedbygravesdisease AT jamalimomal caseofthromboticthrombocytopenicpurpurapossiblyinducedbygravesdisease AT ghaffarimuhammadabuzar caseofthromboticthrombocytopenicpurpurapossiblyinducedbygravesdisease |