Enhanced virulence and waning vaccine-elicited antibodies account for breakthrough infections caused by SARS-CoV-2 delta and beyond

Here we interrogate the factors responsible for SARS-CoV-2 breakthrough infections in a K18-hACE2 transgenic mouse model. We show that Delta and the closely related Kappa variant cause viral pneumonia and severe lung lesions in K18-hACE2 mice. Human COVID-19 mRNA post-vaccination sera after the 2(nd...

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Detalles Bibliográficos
Autores principales: Kwon, Hyung-Joon, Kosikova, Martina, Tang, Weichun, Ortega-Rodriguez, Uriel, Radvak, Peter, Xiang, Ruoxuan, Mercer, Kelly E., Muskhelishvili, Levan, Davis, Kelly, Ward, Jerrold M., Kosik, Ivan, Holly, Jaroslav, Kang, Insung, Yewdell, Jonathan W., Plant, Ewan P., Chen, Wilbur H., Shriver, Mallory C., Barnes, Robin S., Pasetti, Marcela F., Zhou, Bin, Wentworth, David E., Xie, Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635945/
https://www.ncbi.nlm.nih.gov/pubmed/36373096
http://dx.doi.org/10.1016/j.isci.2022.105507

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