Alternative cleavage and polyadenylation generates downstream uncapped RNA isoforms with translation potential

The use of alternative promoters, splicing, and cleavage and polyadenylation (APA) generates mRNA isoforms that expand the diversity and complexity of the transcriptome. Here, we uncovered thousands of previously undescribed 5′ uncapped and polyadenylated transcripts (5′ UPTs). We show that these tr...

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Detalles Bibliográficos
Autores principales: Malka, Yuval, Alkan, Ferhat, Ju, Shinyeong, Körner, Pierre-Rene, Pataskar, Abhijeet, Shulman, Eldad, Loayza-Puch, Fabricio, Champagne, Julien, Wenzel, Casper, Faller, William James, Elkon, Ran, Lee, Cheolju, Agami, Reuven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636002/
https://www.ncbi.nlm.nih.gov/pubmed/36270248
http://dx.doi.org/10.1016/j.molcel.2022.09.036

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