The emerging importance of METTL5-mediated ribosomal RNA methylation

The study of the epitranscriptome has thus far focused largely on mRNA methylation. Recent human genetics studies suggest that methylation of ribosomal RNA also contributes to brain development and cognition. In particular, the m(6)A modification at the A-1832 position of the 18S rRNA is installed b...

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Autores principales: Turkalj, Elena M., Vissers, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636144/
https://www.ncbi.nlm.nih.gov/pubmed/36266443
http://dx.doi.org/10.1038/s12276-022-00869-y
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author Turkalj, Elena M.
Vissers, Caroline
author_facet Turkalj, Elena M.
Vissers, Caroline
author_sort Turkalj, Elena M.
collection PubMed
description The study of the epitranscriptome has thus far focused largely on mRNA methylation. Recent human genetics studies suggest that methylation of ribosomal RNA also contributes to brain development and cognition. In particular, the m(6)A modification at the A-1832 position of the 18S rRNA is installed by METTL5. Mutations or deletions of Mettl5 in humans and mice, respectively, cause abnormal translation and gene expression that in turn mediates stem cell behaviors such as differentiation. In this review, we provide an overview of the current knowledge of the methyltransferase METTL5, as well as the molecular biology surrounding m(6)A on rRNA and how it regulates cell behavior.
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spelling pubmed-96361442022-11-28 The emerging importance of METTL5-mediated ribosomal RNA methylation Turkalj, Elena M. Vissers, Caroline Exp Mol Med Review Article The study of the epitranscriptome has thus far focused largely on mRNA methylation. Recent human genetics studies suggest that methylation of ribosomal RNA also contributes to brain development and cognition. In particular, the m(6)A modification at the A-1832 position of the 18S rRNA is installed by METTL5. Mutations or deletions of Mettl5 in humans and mice, respectively, cause abnormal translation and gene expression that in turn mediates stem cell behaviors such as differentiation. In this review, we provide an overview of the current knowledge of the methyltransferase METTL5, as well as the molecular biology surrounding m(6)A on rRNA and how it regulates cell behavior. Nature Publishing Group UK 2022-10-21 /pmc/articles/PMC9636144/ /pubmed/36266443 http://dx.doi.org/10.1038/s12276-022-00869-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Turkalj, Elena M.
Vissers, Caroline
The emerging importance of METTL5-mediated ribosomal RNA methylation
title The emerging importance of METTL5-mediated ribosomal RNA methylation
title_full The emerging importance of METTL5-mediated ribosomal RNA methylation
title_fullStr The emerging importance of METTL5-mediated ribosomal RNA methylation
title_full_unstemmed The emerging importance of METTL5-mediated ribosomal RNA methylation
title_short The emerging importance of METTL5-mediated ribosomal RNA methylation
title_sort emerging importance of mettl5-mediated ribosomal rna methylation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636144/
https://www.ncbi.nlm.nih.gov/pubmed/36266443
http://dx.doi.org/10.1038/s12276-022-00869-y
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