Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function

Tight control of cell fate choices is crucial for normal development. Here we show that lamin A/C plays a key role in chromatin organization in embryonic stem cells (ESCs), which safeguards naïve pluripotency and ensures proper cell fate choices during cardiogenesis. We report changes in chromatin c...

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Detalles Bibliográficos
Autores principales: Wang, Yinuo, Elsherbiny, Adel, Kessler, Linda, Cordero, Julio, Shi, Haojie, Serke, Heike, Lityagina, Olga, Trogisch, Felix A., Mohammadi, Mona Malek, El-Battrawy, Ibrahim, Backs, Johannes, Wieland, Thomas, Heineke, Joerg, Dobreva, Gergana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636150/
https://www.ncbi.nlm.nih.gov/pubmed/36333314
http://dx.doi.org/10.1038/s41467-022-34366-7

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