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Conditioned medium from BV2 microglial cells having polyleucine specifically alters startle response in mice

Repeat-associated non-AUG translation (RAN translation) is observed in transcripts that are causative for polyglutamine (polyQ) diseases and generates proteins with mono amino acid tracts such as polyalanine (polyA), polyleucine (polyL) and polyserine (polyS) in neurons, astrocytes and microglia. We...

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Detalles Bibliográficos
Autores principales: Owada, Ryuji, Kakuta, Yohei, Yoshida, Kosuke, Mitsui, Shinichi, Nakamura, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636192/
https://www.ncbi.nlm.nih.gov/pubmed/36333586
http://dx.doi.org/10.1038/s41598-022-23571-5

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