Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection

The impact of bone cell activation on bacterially-induced osteolysis remains elusive. Here, we show that matrix-embedded osteocytes stimulated with bacterial pathogen-associated molecular patterns (PAMPs) directly drive bone resorption through an MYD88-regulated signaling pathway. Mice lacking MYD88...

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Detalles Bibliográficos
Autores principales: Yoshimoto, Tetsuya, Kittaka, Mizuho, Doan, Andrew Anh Phuong, Urata, Rina, Prideaux, Matthew, Rojas, Roxana E., Harding, Clifford V., Henry Boom, W., Bonewald, Lynda F., Greenfield, Edward M., Ueki, Yasuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636212/
https://www.ncbi.nlm.nih.gov/pubmed/36333322
http://dx.doi.org/10.1038/s41467-022-34352-z

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