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Computational analysis of arrhythmogenesis in KCNH2 T618I mutation-associated short QT syndrome and the pharmacological effects of quinidine and sotalol

Short QT syndrome (SQTS) is a rare but dangerous genetic disease. In this research, we conducted a comprehensive in silico investigation into the arrhythmogenesis in KCNH2 T618I-associated SQTS using a multi-scale human ventricle model. A Markov chain model of I(Kr) was developed firstly to reproduc...

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Detalles Bibliográficos
Autores principales:	Zhang, Shugang, Lu, Weigang, Yang, Fei, Li, Zhen, Wang, Shuang, Jiang, Mingjian, Wang, Xiaofeng, Wei, Zhiqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636227/ https://www.ncbi.nlm.nih.gov/pubmed/36333337 http://dx.doi.org/10.1038/s41540-022-00254-5

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