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Cochlear motion across the reticular lamina implies that it is not a stiff plate
Within the cochlea, the basilar membrane (BM) is coupled to the reticular lamina (RL) through three rows of piezo-like outer hair cells (OHCs) and supporting cells that endow mammals with sensitive hearing. Anatomical differences across OHC rows suggest differences in their motion. Using optical coh...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636238/ https://www.ncbi.nlm.nih.gov/pubmed/36333415 http://dx.doi.org/10.1038/s41598-022-23525-x |
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author | Cho, Nam Hyun Puria, Sunil |
author_facet | Cho, Nam Hyun Puria, Sunil |
author_sort | Cho, Nam Hyun |
collection | PubMed |
description | Within the cochlea, the basilar membrane (BM) is coupled to the reticular lamina (RL) through three rows of piezo-like outer hair cells (OHCs) and supporting cells that endow mammals with sensitive hearing. Anatomical differences across OHC rows suggest differences in their motion. Using optical coherence tomography, we measured in vivo and postmortem displacements through the gerbil round-window membrane from approximately the 40–47 kHz best-frequency (BF) regions. Our high spatial resolution allowed measurements across the RL surface at the tops of the three rows of individual OHCs and their bottoms, and across the BM. RL motion varied radially; the third-row gain was more than 3 times greater than that of the first row near BF, whereas the OHC-bottom motions remained similar. This implies that the RL mosaic, comprised of OHC and phalangeal-process tops joined together by adhesion molecules, is much more flexible than the Deiters’ cells connected to the OHCs at their bottom surfaces. Postmortem, the measured points moved together approximately in phase. These imply that in vivo, the RL does not move as a stiff plate hinging around the pillar-cell heads near the first row as has been assumed, but that its mosaic-like structure may instead bend and/or stretch. |
format | Online Article Text |
id | pubmed-9636238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-96362382022-11-06 Cochlear motion across the reticular lamina implies that it is not a stiff plate Cho, Nam Hyun Puria, Sunil Sci Rep Article Within the cochlea, the basilar membrane (BM) is coupled to the reticular lamina (RL) through three rows of piezo-like outer hair cells (OHCs) and supporting cells that endow mammals with sensitive hearing. Anatomical differences across OHC rows suggest differences in their motion. Using optical coherence tomography, we measured in vivo and postmortem displacements through the gerbil round-window membrane from approximately the 40–47 kHz best-frequency (BF) regions. Our high spatial resolution allowed measurements across the RL surface at the tops of the three rows of individual OHCs and their bottoms, and across the BM. RL motion varied radially; the third-row gain was more than 3 times greater than that of the first row near BF, whereas the OHC-bottom motions remained similar. This implies that the RL mosaic, comprised of OHC and phalangeal-process tops joined together by adhesion molecules, is much more flexible than the Deiters’ cells connected to the OHCs at their bottom surfaces. Postmortem, the measured points moved together approximately in phase. These imply that in vivo, the RL does not move as a stiff plate hinging around the pillar-cell heads near the first row as has been assumed, but that its mosaic-like structure may instead bend and/or stretch. Nature Publishing Group UK 2022-11-04 /pmc/articles/PMC9636238/ /pubmed/36333415 http://dx.doi.org/10.1038/s41598-022-23525-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Cho, Nam Hyun Puria, Sunil Cochlear motion across the reticular lamina implies that it is not a stiff plate |
title | Cochlear motion across the reticular lamina implies that it is not a stiff plate |
title_full | Cochlear motion across the reticular lamina implies that it is not a stiff plate |
title_fullStr | Cochlear motion across the reticular lamina implies that it is not a stiff plate |
title_full_unstemmed | Cochlear motion across the reticular lamina implies that it is not a stiff plate |
title_short | Cochlear motion across the reticular lamina implies that it is not a stiff plate |
title_sort | cochlear motion across the reticular lamina implies that it is not a stiff plate |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636238/ https://www.ncbi.nlm.nih.gov/pubmed/36333415 http://dx.doi.org/10.1038/s41598-022-23525-x |
work_keys_str_mv | AT chonamhyun cochlearmotionacrossthereticularlaminaimpliesthatitisnotastiffplate AT puriasunil cochlearmotionacrossthereticularlaminaimpliesthatitisnotastiffplate |