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Radiation dose and gene expression analysis of wild boar 10 years after the Fukushima Daiichi Nuclear Plant accident
The Fukushima Daiichi Nuclear Power Plant accident led to contamination with radioactive cesium in an extensive environment in Japan in 2011. We evaluated the concentration of radioactive cesium in the skeletal muscles of 22 wild boars and the expression of IFN-γ, TLR3, and CyclinG1 in the small int...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636247/ https://www.ncbi.nlm.nih.gov/pubmed/36333381 http://dx.doi.org/10.1038/s41598-022-21436-5 |
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author | Morimoto, Motoko Kobayashi, Jin Kino, Yasushi |
author_facet | Morimoto, Motoko Kobayashi, Jin Kino, Yasushi |
author_sort | Morimoto, Motoko |
collection | PubMed |
description | The Fukushima Daiichi Nuclear Power Plant accident led to contamination with radioactive cesium in an extensive environment in Japan in 2011. We evaluated the concentration of radioactive cesium in the skeletal muscles of 22 wild boars and the expression of IFN-γ, TLR3, and CyclinG1 in the small intestine and compared them with those of wild boar samples collected from Hyogo prefecture. The average (137)Cs radioactivity concentration in wild boars in the ex-evacuation zone was 470 Bq/kg. Most of samples still showed radioactivity concentration that exceeded the regulatory limit for foods, but the dose remarkably decreased compared with samples just after the accident. IFN-γ expression was significantly higher in wild boars in the ex-evacuation zone than in samples from Hyogo prefecture. TLR3 expression was also upregulated. CyclinG1 expression also tended to be high. Hence, wild boars might have received some effects of low-dose radiation, and immune cells were activated to some extent. However, pathological examination revealed no inflammatory cell infiltration or pathological damage in the small intestine of wild boars in the ex-evacuation area. Long-term monitoring would be necessary, but we consider that the living body responds appropriately to a stimulus from a contaminated environment. |
format | Online Article Text |
id | pubmed-9636247 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-96362472022-11-06 Radiation dose and gene expression analysis of wild boar 10 years after the Fukushima Daiichi Nuclear Plant accident Morimoto, Motoko Kobayashi, Jin Kino, Yasushi Sci Rep Article The Fukushima Daiichi Nuclear Power Plant accident led to contamination with radioactive cesium in an extensive environment in Japan in 2011. We evaluated the concentration of radioactive cesium in the skeletal muscles of 22 wild boars and the expression of IFN-γ, TLR3, and CyclinG1 in the small intestine and compared them with those of wild boar samples collected from Hyogo prefecture. The average (137)Cs radioactivity concentration in wild boars in the ex-evacuation zone was 470 Bq/kg. Most of samples still showed radioactivity concentration that exceeded the regulatory limit for foods, but the dose remarkably decreased compared with samples just after the accident. IFN-γ expression was significantly higher in wild boars in the ex-evacuation zone than in samples from Hyogo prefecture. TLR3 expression was also upregulated. CyclinG1 expression also tended to be high. Hence, wild boars might have received some effects of low-dose radiation, and immune cells were activated to some extent. However, pathological examination revealed no inflammatory cell infiltration or pathological damage in the small intestine of wild boars in the ex-evacuation area. Long-term monitoring would be necessary, but we consider that the living body responds appropriately to a stimulus from a contaminated environment. Nature Publishing Group UK 2022-11-04 /pmc/articles/PMC9636247/ /pubmed/36333381 http://dx.doi.org/10.1038/s41598-022-21436-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Morimoto, Motoko Kobayashi, Jin Kino, Yasushi Radiation dose and gene expression analysis of wild boar 10 years after the Fukushima Daiichi Nuclear Plant accident |
title | Radiation dose and gene expression analysis of wild boar 10 years after the Fukushima Daiichi Nuclear Plant accident |
title_full | Radiation dose and gene expression analysis of wild boar 10 years after the Fukushima Daiichi Nuclear Plant accident |
title_fullStr | Radiation dose and gene expression analysis of wild boar 10 years after the Fukushima Daiichi Nuclear Plant accident |
title_full_unstemmed | Radiation dose and gene expression analysis of wild boar 10 years after the Fukushima Daiichi Nuclear Plant accident |
title_short | Radiation dose and gene expression analysis of wild boar 10 years after the Fukushima Daiichi Nuclear Plant accident |
title_sort | radiation dose and gene expression analysis of wild boar 10 years after the fukushima daiichi nuclear plant accident |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636247/ https://www.ncbi.nlm.nih.gov/pubmed/36333381 http://dx.doi.org/10.1038/s41598-022-21436-5 |
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