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The use of biological amniotic membranes in the treatment of recurrent macular holes

To evaluate the clinical therapeutic effects of a technique in which biological amniotic membranes (bAMs) are used in the treatment of patients with recurrent macular holes. In this prospective nonrandomized case series study, 23 eyes of 23 patients with recurrent macular holes who had already under...

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Autores principales: Qiao, Gang, Xie, Lijun, Zou, Qiangxing, He, Chunmei, Zhang, Xiaojuan, Tang, Ziyan, Zou, Shuai, Cao, Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636383/
https://www.ncbi.nlm.nih.gov/pubmed/36333334
http://dx.doi.org/10.1038/s41598-022-21754-8
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author Qiao, Gang
Xie, Lijun
Zou, Qiangxing
He, Chunmei
Zhang, Xiaojuan
Tang, Ziyan
Zou, Shuai
Cao, Kui
author_facet Qiao, Gang
Xie, Lijun
Zou, Qiangxing
He, Chunmei
Zhang, Xiaojuan
Tang, Ziyan
Zou, Shuai
Cao, Kui
author_sort Qiao, Gang
collection PubMed
description To evaluate the clinical therapeutic effects of a technique in which biological amniotic membranes (bAMs) are used in the treatment of patients with recurrent macular holes. In this prospective nonrandomized case series study, 23 eyes of 23 patients with recurrent macular holes who had already undergone surgery with pars plana vitrectomy with internal limiting membrane peeling were evaluated. In the surgery, a bAM was used to cover the macular area, and C(3)F(8) tamponade was performed on these patients. Phacoemulsification combined with intraocular lens implantation was performed simultaneously in patients who had cataracts. Patients were followed up for at least half a year. The main outcomes were whether the macular hole closed, the morphological changes in the macular graft, the best-corrected visual acuity, intraocular pressure (IOP) and other indicators. In all eyes, the recurrent macular holes were closed. Two cases (8.69%, 2/23) had bAM shifting half a month after surgery, and these patients underwent a second surgery to adjust the position of the bAM and perform C3F8 tamponade. In the 6-month follow-up, 21 patients (91.30%, 21/23) had improved visual acuity (VA), and 2 patients (8.69%, 2/23) had no change in VA. The mean VA increased from 1.73 ± 0.32 before surgery to 1.12 ± 0.42 after surgery (t = 10.63, P = 0.00 < 0.01), and the mean IOP decreased from 22.13 ± 5.56 before surgery to 17.23 ± 1.71 after surgery (t = 5.14, P = 0.00 < 0.01). No serious complications occurred in any of the cases. The technique of using a biological amniotic membrane can be an effective treatment for patients with recurrent macular holes.
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spelling pubmed-96363832022-11-06 The use of biological amniotic membranes in the treatment of recurrent macular holes Qiao, Gang Xie, Lijun Zou, Qiangxing He, Chunmei Zhang, Xiaojuan Tang, Ziyan Zou, Shuai Cao, Kui Sci Rep Article To evaluate the clinical therapeutic effects of a technique in which biological amniotic membranes (bAMs) are used in the treatment of patients with recurrent macular holes. In this prospective nonrandomized case series study, 23 eyes of 23 patients with recurrent macular holes who had already undergone surgery with pars plana vitrectomy with internal limiting membrane peeling were evaluated. In the surgery, a bAM was used to cover the macular area, and C(3)F(8) tamponade was performed on these patients. Phacoemulsification combined with intraocular lens implantation was performed simultaneously in patients who had cataracts. Patients were followed up for at least half a year. The main outcomes were whether the macular hole closed, the morphological changes in the macular graft, the best-corrected visual acuity, intraocular pressure (IOP) and other indicators. In all eyes, the recurrent macular holes were closed. Two cases (8.69%, 2/23) had bAM shifting half a month after surgery, and these patients underwent a second surgery to adjust the position of the bAM and perform C3F8 tamponade. In the 6-month follow-up, 21 patients (91.30%, 21/23) had improved visual acuity (VA), and 2 patients (8.69%, 2/23) had no change in VA. The mean VA increased from 1.73 ± 0.32 before surgery to 1.12 ± 0.42 after surgery (t = 10.63, P = 0.00 < 0.01), and the mean IOP decreased from 22.13 ± 5.56 before surgery to 17.23 ± 1.71 after surgery (t = 5.14, P = 0.00 < 0.01). No serious complications occurred in any of the cases. The technique of using a biological amniotic membrane can be an effective treatment for patients with recurrent macular holes. Nature Publishing Group UK 2022-11-04 /pmc/articles/PMC9636383/ /pubmed/36333334 http://dx.doi.org/10.1038/s41598-022-21754-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Qiao, Gang
Xie, Lijun
Zou, Qiangxing
He, Chunmei
Zhang, Xiaojuan
Tang, Ziyan
Zou, Shuai
Cao, Kui
The use of biological amniotic membranes in the treatment of recurrent macular holes
title The use of biological amniotic membranes in the treatment of recurrent macular holes
title_full The use of biological amniotic membranes in the treatment of recurrent macular holes
title_fullStr The use of biological amniotic membranes in the treatment of recurrent macular holes
title_full_unstemmed The use of biological amniotic membranes in the treatment of recurrent macular holes
title_short The use of biological amniotic membranes in the treatment of recurrent macular holes
title_sort use of biological amniotic membranes in the treatment of recurrent macular holes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636383/
https://www.ncbi.nlm.nih.gov/pubmed/36333334
http://dx.doi.org/10.1038/s41598-022-21754-8
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