Defective VWF secretion due to expression of MYH9-RD E1841K mutant in endothelial cells disrupts hemostasis

Mutations in MYH9, the gene encoding the heavy chain of nonmuscle myosin IIa (NMII-A), cause MYH9-related disease (MYH9-RD), which is an autosomal-dominant thrombocytopenia with bleeding tendency. Previously, we showed that NMII-A in endothelial cells (ECs) is critical for hemostasis via regulating...

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Detalles Bibliográficos
Autores principales: Cao, Yang, Sun, Yanjie, Deng, Yanan, Wei, Guoqin, Liu, Junling, Jin, Shengyu, Dong, Chao, Kang, Xuya, Huo, Yingqing, Zhang, Jingjing, Luo, Jincai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Vascular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636428/
https://www.ncbi.nlm.nih.gov/pubmed/35764499
http://dx.doi.org/10.1182/bloodadvances.2022008011

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