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PGLN: A newly identified amino phosphoglycolipid species in Thermus thermophilus HB8
Thermus thermophilus has several minor lipid molecules with structures that have not been described yet. In this study, we identified a new lipid molecule in T. thermophilus HB8 with an amino group at the polar head, by detecting lipid spots with HPTLC and mass spectrometry. The structure of the lip...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636437/ https://www.ncbi.nlm.nih.gov/pubmed/36345289 http://dx.doi.org/10.1016/j.bbrep.2022.101377 |
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author | Nemoto, Naoki Kawaguchi, Masahiko Yura, Kei Shimada, Haruo Bessho, Yoshitaka |
author_facet | Nemoto, Naoki Kawaguchi, Masahiko Yura, Kei Shimada, Haruo Bessho, Yoshitaka |
author_sort | Nemoto, Naoki |
collection | PubMed |
description | Thermus thermophilus has several minor lipid molecules with structures that have not been described yet. In this study, we identified a new lipid molecule in T. thermophilus HB8 with an amino group at the polar head, by detecting lipid spots with HPTLC and mass spectrometry. The structure of the lipid resembles an amino sugar phospholipid, except for the glucosamine that lacks an acetyl group. We named this amino phosphoglycolipid PGLN, and proposed its synthetic pathway from a precursor, phosphatidyl-glyceric alkylamine. The primary amine structure of PGLN may contribute to high temperature adaptation through electrostatic interactions between the head groups. |
format | Online Article Text |
id | pubmed-9636437 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-96364372022-11-06 PGLN: A newly identified amino phosphoglycolipid species in Thermus thermophilus HB8 Nemoto, Naoki Kawaguchi, Masahiko Yura, Kei Shimada, Haruo Bessho, Yoshitaka Biochem Biophys Rep Short Communication Thermus thermophilus has several minor lipid molecules with structures that have not been described yet. In this study, we identified a new lipid molecule in T. thermophilus HB8 with an amino group at the polar head, by detecting lipid spots with HPTLC and mass spectrometry. The structure of the lipid resembles an amino sugar phospholipid, except for the glucosamine that lacks an acetyl group. We named this amino phosphoglycolipid PGLN, and proposed its synthetic pathway from a precursor, phosphatidyl-glyceric alkylamine. The primary amine structure of PGLN may contribute to high temperature adaptation through electrostatic interactions between the head groups. Elsevier 2022-11-02 /pmc/articles/PMC9636437/ /pubmed/36345289 http://dx.doi.org/10.1016/j.bbrep.2022.101377 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Short Communication Nemoto, Naoki Kawaguchi, Masahiko Yura, Kei Shimada, Haruo Bessho, Yoshitaka PGLN: A newly identified amino phosphoglycolipid species in Thermus thermophilus HB8 |
title | PGLN: A newly identified amino phosphoglycolipid species in Thermus thermophilus HB8 |
title_full | PGLN: A newly identified amino phosphoglycolipid species in Thermus thermophilus HB8 |
title_fullStr | PGLN: A newly identified amino phosphoglycolipid species in Thermus thermophilus HB8 |
title_full_unstemmed | PGLN: A newly identified amino phosphoglycolipid species in Thermus thermophilus HB8 |
title_short | PGLN: A newly identified amino phosphoglycolipid species in Thermus thermophilus HB8 |
title_sort | pgln: a newly identified amino phosphoglycolipid species in thermus thermophilus hb8 |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636437/ https://www.ncbi.nlm.nih.gov/pubmed/36345289 http://dx.doi.org/10.1016/j.bbrep.2022.101377 |
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