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Genome-wide association analysis of the primary feather growth traits of duck: identification of potential Loci for growth regulation

The feather is an important epidermal appendage, plays an important role in the life activities of avian specie, and has important economic value. Revealing the molecular regulation mechanism of feather growth has a significant meaning in studying adaptive evolution, physiology, and mating of avian...

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Autores principales: Ma, Shengchao, Li, Pengcheng, Liu, Hehe, Xi, Yang, Xu, Qian, Qi, Jingjing, Wang, Jianmei, Li, Liang, Wang, Jiwen, Hu, Jiwei, He, Hua, Han, Chunchun, Bai, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636485/
https://www.ncbi.nlm.nih.gov/pubmed/36334470
http://dx.doi.org/10.1016/j.psj.2022.102243
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author Ma, Shengchao
Li, Pengcheng
Liu, Hehe
Xi, Yang
Xu, Qian
Qi, Jingjing
Wang, Jianmei
Li, Liang
Wang, Jiwen
Hu, Jiwei
He, Hua
Han, Chunchun
Bai, Lili
author_facet Ma, Shengchao
Li, Pengcheng
Liu, Hehe
Xi, Yang
Xu, Qian
Qi, Jingjing
Wang, Jianmei
Li, Liang
Wang, Jiwen
Hu, Jiwei
He, Hua
Han, Chunchun
Bai, Lili
author_sort Ma, Shengchao
collection PubMed
description The feather is an important epidermal appendage, plays an important role in the life activities of avian specie, and has important economic value. Revealing the molecular regulation mechanism of feather growth has a significant meaning in studying adaptive evolution, physiology, and mating of avian species and also provides a theoretical reference for poultry breeding. In this study, the genome-wide association analysis (GWAS) of 358 ducks was based on primary feather length phenotypic data (28–60 d), length growth rates (LGRs), and maturity scores (60 d) to explore the genetic basis affecting feather growth and maturation. The results showed that, among the primary feather 1 to 5 in ducks, the mean LGR of primary feather 2 was the fastest, with the longest length. The primary feathers in males grew and matured slightly faster than in females. The mean maturity scores of primary feather 10∼7 were higher than primary feather 1 to 3 in ducks. GWAS further showed 116 SNPs associated with feather length traits. In addition, 2 candidate regions (Chr1: 127,407,230–127,524,879 bp and Chr21: 182,061,707–183,616,298 bp) were associated with LGR, which contain total 13 candidate genes (The extremely significant SNPs were mainly located in 2 genes: Chr1: REPS2 and Chr21: PTPRT). Four candidate regions (Chr1: 29,113,036–28,675,018 bp, Chr2: 18,253,612–149,111,290 bp, Chr15: 6,489,774 to 12,138,221 bp and Chr21: 6,578,021–8,472,904 bp) were associated with feather maturity, which contain total 24 candidate genes (The extremely significant SNPs were mainly located in 4 genes: Chr1: IMMP2L, DOCK4 and DDX10, Chr2: LDLRAD4). In conclusion, sex factors influence feather growth and maturity, and the genetic basis of the growth /maturity trait between different feathers is similar. REPS2, PTPRT genes, and IMMP2L, DOCK4, DDX10, and LDLRAD4 are important candidate genes that influence feather growth and maturity, respectively.
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spelling pubmed-96364852022-11-06 Genome-wide association analysis of the primary feather growth traits of duck: identification of potential Loci for growth regulation Ma, Shengchao Li, Pengcheng Liu, Hehe Xi, Yang Xu, Qian Qi, Jingjing Wang, Jianmei Li, Liang Wang, Jiwen Hu, Jiwei He, Hua Han, Chunchun Bai, Lili Poult Sci GENETICS AND MOLECULAR BIOLOGY The feather is an important epidermal appendage, plays an important role in the life activities of avian specie, and has important economic value. Revealing the molecular regulation mechanism of feather growth has a significant meaning in studying adaptive evolution, physiology, and mating of avian species and also provides a theoretical reference for poultry breeding. In this study, the genome-wide association analysis (GWAS) of 358 ducks was based on primary feather length phenotypic data (28–60 d), length growth rates (LGRs), and maturity scores (60 d) to explore the genetic basis affecting feather growth and maturation. The results showed that, among the primary feather 1 to 5 in ducks, the mean LGR of primary feather 2 was the fastest, with the longest length. The primary feathers in males grew and matured slightly faster than in females. The mean maturity scores of primary feather 10∼7 were higher than primary feather 1 to 3 in ducks. GWAS further showed 116 SNPs associated with feather length traits. In addition, 2 candidate regions (Chr1: 127,407,230–127,524,879 bp and Chr21: 182,061,707–183,616,298 bp) were associated with LGR, which contain total 13 candidate genes (The extremely significant SNPs were mainly located in 2 genes: Chr1: REPS2 and Chr21: PTPRT). Four candidate regions (Chr1: 29,113,036–28,675,018 bp, Chr2: 18,253,612–149,111,290 bp, Chr15: 6,489,774 to 12,138,221 bp and Chr21: 6,578,021–8,472,904 bp) were associated with feather maturity, which contain total 24 candidate genes (The extremely significant SNPs were mainly located in 4 genes: Chr1: IMMP2L, DOCK4 and DDX10, Chr2: LDLRAD4). In conclusion, sex factors influence feather growth and maturity, and the genetic basis of the growth /maturity trait between different feathers is similar. REPS2, PTPRT genes, and IMMP2L, DOCK4, DDX10, and LDLRAD4 are important candidate genes that influence feather growth and maturity, respectively. Elsevier 2022-10-13 /pmc/articles/PMC9636485/ /pubmed/36334470 http://dx.doi.org/10.1016/j.psj.2022.102243 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle GENETICS AND MOLECULAR BIOLOGY
Ma, Shengchao
Li, Pengcheng
Liu, Hehe
Xi, Yang
Xu, Qian
Qi, Jingjing
Wang, Jianmei
Li, Liang
Wang, Jiwen
Hu, Jiwei
He, Hua
Han, Chunchun
Bai, Lili
Genome-wide association analysis of the primary feather growth traits of duck: identification of potential Loci for growth regulation
title Genome-wide association analysis of the primary feather growth traits of duck: identification of potential Loci for growth regulation
title_full Genome-wide association analysis of the primary feather growth traits of duck: identification of potential Loci for growth regulation
title_fullStr Genome-wide association analysis of the primary feather growth traits of duck: identification of potential Loci for growth regulation
title_full_unstemmed Genome-wide association analysis of the primary feather growth traits of duck: identification of potential Loci for growth regulation
title_short Genome-wide association analysis of the primary feather growth traits of duck: identification of potential Loci for growth regulation
title_sort genome-wide association analysis of the primary feather growth traits of duck: identification of potential loci for growth regulation
topic GENETICS AND MOLECULAR BIOLOGY
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636485/
https://www.ncbi.nlm.nih.gov/pubmed/36334470
http://dx.doi.org/10.1016/j.psj.2022.102243
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