MqsR is a noncanonical microbial RNase toxin that is inhibited by antitoxin MqsA via steric blockage of substrate binding

The MqsRA toxin-antitoxin system is a component of the Escherichia coli stress response. Free MqsR, a ribonuclease, cleaves mRNAs containing a 5′-GC-3′ sequence causing a global shutdown of translation and the cell to enter a state of dormancy. Despite a general understanding of MqsR function, the m...

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Detalles Bibliográficos
Autores principales: Yu, Victor, Ronzone, Erik, Lord, Dana, Peti, Wolfgang, Page, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636575/
https://www.ncbi.nlm.nih.gov/pubmed/36162504
http://dx.doi.org/10.1016/j.jbc.2022.102535

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