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The regulation role and diagnostic value of fibrinogen-like protein 1 revealed by pan-cancer analysis

Although the role of fibrinogen-like protein 1 (FGL1) in tumorigenesis is well known, a pan-cancer analysis of FGL1 lacks. We used bioinformatics techniques to analyze cancer data from publicly available datasets from The Cancer Genome Atlas, UALCAN, TIMER, Gene Expression Profiling Interactive Anal...

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Autores principales: Yi, Wanwan, Qiao, Tingting, Yang, Ziyu, Hu, Lei, Sun, Mingming, Fan, Hengwei, Xu, Yanping, Lv, Zhongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636576/
https://www.ncbi.nlm.nih.gov/pubmed/36345363
http://dx.doi.org/10.1016/j.mtbio.2022.100470
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author Yi, Wanwan
Qiao, Tingting
Yang, Ziyu
Hu, Lei
Sun, Mingming
Fan, Hengwei
Xu, Yanping
Lv, Zhongwei
author_facet Yi, Wanwan
Qiao, Tingting
Yang, Ziyu
Hu, Lei
Sun, Mingming
Fan, Hengwei
Xu, Yanping
Lv, Zhongwei
author_sort Yi, Wanwan
collection PubMed
description Although the role of fibrinogen-like protein 1 (FGL1) in tumorigenesis is well known, a pan-cancer analysis of FGL1 lacks. We used bioinformatics techniques to analyze cancer data from publicly available datasets from The Cancer Genome Atlas, UALCAN, TIMER, Gene Expression Profiling Interactive Analysis, cBioPortal, Search Tool for the Retrieval of Interacting Genes, and DAVID. FGL1 expression was significantly regulated in various common tumors than in normal tissues; it was increased in lung adenocarcinoma and decreased in colon adenocarcinoma. Cox regression analysis demonstrated that the upregulation of FGL1 expression was correlated with poor overall survival (OS) and disease-free survival (DFS) in stomach adenocarcinoma, brain low-grade glioma, cervical squamous cell carcinoma, and endocervical adenocarcinoma. Decreased FGL1 methylation levels were observed in majority of tumor types. FGL1 expression was significantly associated with the levels of immune cell subtypes and immune checkpoint genes. Deep deletion was the most common genetic mutation in FGL1 that led to frame-shift mutations, which was closely associated with poor progression-free interval, disease-specific survival, and OS in patients with FGL1 mutations. Kyoto Encyclopedia of Genes and Genomes enrichment analysis showed that FGL1-related genes participate in diverse pathways. Ubiquitin-mediated proteolysis is significantly correlated to the function of FGL1, which was identified for the first time in the present study. This pan-cancer study provides a deep understanding of the functions of FGL1 in progression of many tumors and demonstrates that FGL1 may be a potential biomarker for the diagnosis, prognosis, and immune infiltration in cancer.
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spelling pubmed-96365762022-11-06 The regulation role and diagnostic value of fibrinogen-like protein 1 revealed by pan-cancer analysis Yi, Wanwan Qiao, Tingting Yang, Ziyu Hu, Lei Sun, Mingming Fan, Hengwei Xu, Yanping Lv, Zhongwei Mater Today Bio Advanced Materials for Disease Diagnosis edited by Kun Qian; Lin Huang Although the role of fibrinogen-like protein 1 (FGL1) in tumorigenesis is well known, a pan-cancer analysis of FGL1 lacks. We used bioinformatics techniques to analyze cancer data from publicly available datasets from The Cancer Genome Atlas, UALCAN, TIMER, Gene Expression Profiling Interactive Analysis, cBioPortal, Search Tool for the Retrieval of Interacting Genes, and DAVID. FGL1 expression was significantly regulated in various common tumors than in normal tissues; it was increased in lung adenocarcinoma and decreased in colon adenocarcinoma. Cox regression analysis demonstrated that the upregulation of FGL1 expression was correlated with poor overall survival (OS) and disease-free survival (DFS) in stomach adenocarcinoma, brain low-grade glioma, cervical squamous cell carcinoma, and endocervical adenocarcinoma. Decreased FGL1 methylation levels were observed in majority of tumor types. FGL1 expression was significantly associated with the levels of immune cell subtypes and immune checkpoint genes. Deep deletion was the most common genetic mutation in FGL1 that led to frame-shift mutations, which was closely associated with poor progression-free interval, disease-specific survival, and OS in patients with FGL1 mutations. Kyoto Encyclopedia of Genes and Genomes enrichment analysis showed that FGL1-related genes participate in diverse pathways. Ubiquitin-mediated proteolysis is significantly correlated to the function of FGL1, which was identified for the first time in the present study. This pan-cancer study provides a deep understanding of the functions of FGL1 in progression of many tumors and demonstrates that FGL1 may be a potential biomarker for the diagnosis, prognosis, and immune infiltration in cancer. Elsevier 2022-10-20 /pmc/articles/PMC9636576/ /pubmed/36345363 http://dx.doi.org/10.1016/j.mtbio.2022.100470 Text en © 2022 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Advanced Materials for Disease Diagnosis edited by Kun Qian; Lin Huang
Yi, Wanwan
Qiao, Tingting
Yang, Ziyu
Hu, Lei
Sun, Mingming
Fan, Hengwei
Xu, Yanping
Lv, Zhongwei
The regulation role and diagnostic value of fibrinogen-like protein 1 revealed by pan-cancer analysis
title The regulation role and diagnostic value of fibrinogen-like protein 1 revealed by pan-cancer analysis
title_full The regulation role and diagnostic value of fibrinogen-like protein 1 revealed by pan-cancer analysis
title_fullStr The regulation role and diagnostic value of fibrinogen-like protein 1 revealed by pan-cancer analysis
title_full_unstemmed The regulation role and diagnostic value of fibrinogen-like protein 1 revealed by pan-cancer analysis
title_short The regulation role and diagnostic value of fibrinogen-like protein 1 revealed by pan-cancer analysis
title_sort regulation role and diagnostic value of fibrinogen-like protein 1 revealed by pan-cancer analysis
topic Advanced Materials for Disease Diagnosis edited by Kun Qian; Lin Huang
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636576/
https://www.ncbi.nlm.nih.gov/pubmed/36345363
http://dx.doi.org/10.1016/j.mtbio.2022.100470
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