COVID-19-associated secondary sclerosing cholangitis – A case series of 4 patients

We report a case series of four patients diagnosed with COVID-19-associated secondary sclerosing cholangitis (SSC), a recently described rare late complication of severe COVID-19. Following prolonged stays in the intensive care unit, these patients developed marked sustained cholestasis and jaundice...

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Autores principales: Ferreira, Filipa Bordalo, Mourato, Margarida, Bragança, Sofia, Paulo, Joana Batista, Sismeiro, Rita, Pereira, André, Mónica, Ana Nassauer, Lourenço, Luís Carvalho, Cardoso, Mariana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Masson SAS. 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636600/
https://www.ncbi.nlm.nih.gov/pubmed/36347499
http://dx.doi.org/10.1016/j.clinre.2022.102048
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author Ferreira, Filipa Bordalo
Mourato, Margarida
Bragança, Sofia
Paulo, Joana Batista
Sismeiro, Rita
Pereira, André
Mónica, Ana Nassauer
Lourenço, Luís Carvalho
Cardoso, Mariana
author_facet Ferreira, Filipa Bordalo
Mourato, Margarida
Bragança, Sofia
Paulo, Joana Batista
Sismeiro, Rita
Pereira, André
Mónica, Ana Nassauer
Lourenço, Luís Carvalho
Cardoso, Mariana
author_sort Ferreira, Filipa Bordalo
collection PubMed
description We report a case series of four patients diagnosed with COVID-19-associated secondary sclerosing cholangitis (SSC), a recently described rare late complication of severe COVID-19. Following prolonged stays in the intensive care unit, these patients developed marked sustained cholestasis and jaundice despite clinical improvement. Cholangiography showed beaded appearance of intra-hepatic bile ducts and bile casts were removed in one patient. None of the patients reached normalization of liver enzymes and at least one progressed to liver cirrhosis (follow-up time of 11 to 16 months). COVID-19-associated SSC has a dismal prognosis with rapid progression to advanced chronic liver disease.
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spelling pubmed-96366002022-11-07 COVID-19-associated secondary sclerosing cholangitis – A case series of 4 patients Ferreira, Filipa Bordalo Mourato, Margarida Bragança, Sofia Paulo, Joana Batista Sismeiro, Rita Pereira, André Mónica, Ana Nassauer Lourenço, Luís Carvalho Cardoso, Mariana Clin Res Hepatol Gastroenterol Case Report We report a case series of four patients diagnosed with COVID-19-associated secondary sclerosing cholangitis (SSC), a recently described rare late complication of severe COVID-19. Following prolonged stays in the intensive care unit, these patients developed marked sustained cholestasis and jaundice despite clinical improvement. Cholangiography showed beaded appearance of intra-hepatic bile ducts and bile casts were removed in one patient. None of the patients reached normalization of liver enzymes and at least one progressed to liver cirrhosis (follow-up time of 11 to 16 months). COVID-19-associated SSC has a dismal prognosis with rapid progression to advanced chronic liver disease. The Authors. Published by Elsevier Masson SAS. 2022-12 2022-11-05 /pmc/articles/PMC9636600/ /pubmed/36347499 http://dx.doi.org/10.1016/j.clinre.2022.102048 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Report
Ferreira, Filipa Bordalo
Mourato, Margarida
Bragança, Sofia
Paulo, Joana Batista
Sismeiro, Rita
Pereira, André
Mónica, Ana Nassauer
Lourenço, Luís Carvalho
Cardoso, Mariana
COVID-19-associated secondary sclerosing cholangitis – A case series of 4 patients
title COVID-19-associated secondary sclerosing cholangitis – A case series of 4 patients
title_full COVID-19-associated secondary sclerosing cholangitis – A case series of 4 patients
title_fullStr COVID-19-associated secondary sclerosing cholangitis – A case series of 4 patients
title_full_unstemmed COVID-19-associated secondary sclerosing cholangitis – A case series of 4 patients
title_short COVID-19-associated secondary sclerosing cholangitis – A case series of 4 patients
title_sort covid-19-associated secondary sclerosing cholangitis – a case series of 4 patients
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636600/
https://www.ncbi.nlm.nih.gov/pubmed/36347499
http://dx.doi.org/10.1016/j.clinre.2022.102048
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