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Mitochondrial protective effects caused by the administration of mefenamic acid in sepsis

The pathophysiology of sepsis may involve the activation of the NOD-type receptor containing the pyrin-3 domain (NLPR-3), mitochondrial and oxidative damages. One of the primary essential oxidation products is 8-oxoguanine (8-oxoG), and its accumulation in mitochondrial DNA (mtDNA) induces cell dysf...

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Detalles Bibliográficos
Autores principales:	Dominguini, Diogo, Michels, Monique, Wessler, Leticia B., Streck, Emilio L., Barichello, Tatiana, Dal-Pizzol, Felipe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636698/ https://www.ncbi.nlm.nih.gov/pubmed/36333747 http://dx.doi.org/10.1186/s12974-022-02616-6

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