The pathogenic roles of lncRNA-Taurine upregulated 1 (TUG1) in colorectal cancer

Colorectal cancer (CRC) is a gastrointestinal tumor that develops from the colon, rectum, or appendix. The prognosis of CRC patients especially those with metastatic lesions remains unsatisfactory. Although various conventional methods have been used for the treatment of patients with CRC, the early...

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Autores principales: Azizidoost, Shirin, Nasrolahi, Ava, Ghaedrahmati, Farhoodeh, Kempisty, Bartosz, Mozdziak, Paul, Radoszkiewicz, Klaudia, Farzaneh, Maryam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636703/
https://www.ncbi.nlm.nih.gov/pubmed/36333703
http://dx.doi.org/10.1186/s12935-022-02745-1
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author Azizidoost, Shirin
Nasrolahi, Ava
Ghaedrahmati, Farhoodeh
Kempisty, Bartosz
Mozdziak, Paul
Radoszkiewicz, Klaudia
Farzaneh, Maryam
author_facet Azizidoost, Shirin
Nasrolahi, Ava
Ghaedrahmati, Farhoodeh
Kempisty, Bartosz
Mozdziak, Paul
Radoszkiewicz, Klaudia
Farzaneh, Maryam
author_sort Azizidoost, Shirin
collection PubMed
description Colorectal cancer (CRC) is a gastrointestinal tumor that develops from the colon, rectum, or appendix. The prognosis of CRC patients especially those with metastatic lesions remains unsatisfactory. Although various conventional methods have been used for the treatment of patients with CRC, the early detection and identification of molecular mechanisms associated with CRC is necessary. The scientific literature reports that altered expression of long non-coding RNAs (lncRNAs) contributed to the pathogenesis of CRC cells. LncRNA TUG1 was reported to target various miRNAs and signaling pathways to mediate CRC cell proliferation, migration, and metastasis. Therefore, TUG1 might be a potent predictive/prognostic biomarker for diagnosis of CRC.
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spelling pubmed-96367032022-11-06 The pathogenic roles of lncRNA-Taurine upregulated 1 (TUG1) in colorectal cancer Azizidoost, Shirin Nasrolahi, Ava Ghaedrahmati, Farhoodeh Kempisty, Bartosz Mozdziak, Paul Radoszkiewicz, Klaudia Farzaneh, Maryam Cancer Cell Int Review Colorectal cancer (CRC) is a gastrointestinal tumor that develops from the colon, rectum, or appendix. The prognosis of CRC patients especially those with metastatic lesions remains unsatisfactory. Although various conventional methods have been used for the treatment of patients with CRC, the early detection and identification of molecular mechanisms associated with CRC is necessary. The scientific literature reports that altered expression of long non-coding RNAs (lncRNAs) contributed to the pathogenesis of CRC cells. LncRNA TUG1 was reported to target various miRNAs and signaling pathways to mediate CRC cell proliferation, migration, and metastasis. Therefore, TUG1 might be a potent predictive/prognostic biomarker for diagnosis of CRC. BioMed Central 2022-11-04 /pmc/articles/PMC9636703/ /pubmed/36333703 http://dx.doi.org/10.1186/s12935-022-02745-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Azizidoost, Shirin
Nasrolahi, Ava
Ghaedrahmati, Farhoodeh
Kempisty, Bartosz
Mozdziak, Paul
Radoszkiewicz, Klaudia
Farzaneh, Maryam
The pathogenic roles of lncRNA-Taurine upregulated 1 (TUG1) in colorectal cancer
title The pathogenic roles of lncRNA-Taurine upregulated 1 (TUG1) in colorectal cancer
title_full The pathogenic roles of lncRNA-Taurine upregulated 1 (TUG1) in colorectal cancer
title_fullStr The pathogenic roles of lncRNA-Taurine upregulated 1 (TUG1) in colorectal cancer
title_full_unstemmed The pathogenic roles of lncRNA-Taurine upregulated 1 (TUG1) in colorectal cancer
title_short The pathogenic roles of lncRNA-Taurine upregulated 1 (TUG1) in colorectal cancer
title_sort pathogenic roles of lncrna-taurine upregulated 1 (tug1) in colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636703/
https://www.ncbi.nlm.nih.gov/pubmed/36333703
http://dx.doi.org/10.1186/s12935-022-02745-1
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