Salidroside reduces neuropathology in Alzheimer’s disease models by targeting NRF2/SIRT3 pathway

BACKGROUND: Neurite dystrophy is a pathologic hallmark of Alzheimer’s disease (AD). However, drug discovery targeting neurite protection in AD remains largely unexplored. METHODS: Aβ-induced neurite and mitochondrial damage assays were used to evaluate Aβ toxicity and the neuroprotective efficacy of...

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Detalles Bibliográficos
Autores principales: Yao, Yuyuan, Ren, Zhichu, Yang, Ruihan, Mei, Yilan, Dai, Yuying, Cheng, Qian, Xu, Chong, Xu, Xiaogang, Wang, Sanying, Kim, Kyoung Mi, Noh, Ji Heon, Zhu, Jian, Zhao, Ningwei, Liu, Yong U., Mao, Genxiang, Sima, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636768/
https://www.ncbi.nlm.nih.gov/pubmed/36333711
http://dx.doi.org/10.1186/s13578-022-00918-z

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