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Combinatorial targeting of menin and the histone methyltransferase DOT1L as a novel therapeutic strategy for treatment of chemotherapy-resistant ovarian cancer

BACKGROUND: Ovarian cancer (OC) is characterized by a low response rate and high frequency of resistance development to currently available treatments. The therapeutic potential of histone methyltransferase DOT1L inhibitor in OC cells has been demonstrated, but optimal efficacy and safety of this ta...

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Detalles Bibliográficos
Autores principales:	Alexandrova, Elena, Lamberti, Jessica, Memoli, Domenico, Quercia, Claudia, Melone, Viola, Rizzo, Francesca, Tarallo, Roberta, Giurato, Giorgio, Nassa, Giovanni, Weisz, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636786/ https://www.ncbi.nlm.nih.gov/pubmed/36333801 http://dx.doi.org/10.1186/s12935-022-02740-6

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