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Origin of the 3-methylglutaryl moiety in caprazamycin biosynthesis

BACKGROUND: Caprazamycins are liponucleoside antibiotics showing bioactivity against Gram-positive bacteria including clinically relevant Mycobacterium tuberculosis by targeting the bacterial MraY-translocase. Their chemical structure contains a unique 3-methylglutaryl moiety which they only share w...

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Detalles Bibliográficos
Autores principales:	Bär, Daniel, Konetschny, Benjamin, Kulik, Andreas, Xu, Houchao, Paccagnella, Davide, Beller, Patrick, Ziemert, Nadine, Dickschat, Jeroen S., Gust, Bertolt
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636800/ https://www.ncbi.nlm.nih.gov/pubmed/36335365 http://dx.doi.org/10.1186/s12934-022-01955-6

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