Loss of Brca1 and Trp53 in adult mouse mammary ductal epithelium results in development of hormone receptor-positive or hormone receptor-negative tumors, depending on inactivation of Rb family proteins

BACKGROUND: Breast cancer is a heterogenous disease with several histological and molecular subtypes. Models that represent these subtypes are essential for translational research aimed at improving clinical strategy for targeted therapeutics. METHODS: Different combinations of genetic aberrations (...

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Detalles Bibliográficos
Autores principales: Szabova, Ludmila, Gordon, Melanie B., Lu, Lucy, Pate, Nathan, Bassel, Laura, Iacovelli, Anthony J., Karim, Baktiar, Homan, Philip J., Householder, Deborah B., Guerin, Theresa M., Burkett, Sandra, Day, Amanda M., Custer, Wendi, Weaver Ohler, Zoe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636824/
https://www.ncbi.nlm.nih.gov/pubmed/36333737
http://dx.doi.org/10.1186/s13058-022-01566-4

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