Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood–brain barrier microvessels

The blood–brain barrier (BBB) plays a pivotal role in brain health and disease. In the BBB, brain microvascular endothelial cells (BMECs) are connected by tight junctions which regulate paracellular transport, and express specialized transporter systems which regulate transcellular transport. Howeve...

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Detalles Bibliográficos
Autores principales: Linville, Raleigh M., Sklar, Matthew B., Grifno, Gabrielle N., Nerenberg, Renée F., Zhou, Justin, Ye, Robert, DeStefano, Jackson G., Guo, Zhaobin, Jha, Ria, Jamieson, John J., Zhao, Nan, Searson, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636829/
https://www.ncbi.nlm.nih.gov/pubmed/36333694
http://dx.doi.org/10.1186/s12987-022-00377-1

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