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Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process
Angiogenesis is a vital biological process involving blood vessels forming from pre-existing vascular systems. This process contributes to various physiological activities, including embryonic development, hair growth, ovulation, menstruation, and the repair and regeneration of damaged tissue. On th...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636835/ https://www.ncbi.nlm.nih.gov/pubmed/36333816 http://dx.doi.org/10.1186/s40001-022-00833-6 |
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author | Hoseinzadeh, Ahmad Ghoddusi Johari, Hamed Anbardar, Mohammad Hossein Tayebi, Lobat Vafa, Ehsan Abbasi, Milad Vaez, Ahmad Golchin, Ali Amani, Ali Mohammad Jangjou, Ali |
author_facet | Hoseinzadeh, Ahmad Ghoddusi Johari, Hamed Anbardar, Mohammad Hossein Tayebi, Lobat Vafa, Ehsan Abbasi, Milad Vaez, Ahmad Golchin, Ali Amani, Ali Mohammad Jangjou, Ali |
author_sort | Hoseinzadeh, Ahmad |
collection | PubMed |
description | Angiogenesis is a vital biological process involving blood vessels forming from pre-existing vascular systems. This process contributes to various physiological activities, including embryonic development, hair growth, ovulation, menstruation, and the repair and regeneration of damaged tissue. On the other hand, it is essential in treating a wide range of pathological diseases, such as cardiovascular and ischemic diseases, rheumatoid arthritis, malignancies, ophthalmic and retinal diseases, and other chronic conditions. These diseases and disorders are frequently treated by regulating angiogenesis by utilizing a variety of pro-angiogenic or anti-angiogenic agents or molecules by stimulating or suppressing this complicated process, respectively. Nevertheless, many traditional angiogenic therapy techniques suffer from a lack of ability to achieve the intended therapeutic impact because of various constraints. These disadvantages include limited bioavailability, drug resistance, fast elimination, increased price, nonspecificity, and adverse effects. As a result, it is an excellent time for developing various pro- and anti-angiogenic substances that might circumvent the abovementioned restrictions, followed by their efficient use in treating disorders associated with angiogenesis. In recent years, significant progress has been made in different fields of medicine and biology, including therapeutic angiogenesis. Around the world, a multitude of research groups investigated several inorganic or organic nanoparticles (NPs) that had the potential to effectively modify the angiogenesis processes by either enhancing or suppressing the process. Many studies into the processes behind NP-mediated angiogenesis are well described. In this article, we also cover the application of NPs to encourage tissue vascularization as well as their angiogenic and anti-angiogenic effects in the treatment of several disorders, including bone regeneration, peripheral vascular disease, diabetic retinopathy, ischemic stroke, rheumatoid arthritis, post-ischemic cardiovascular injury, age-related macular degeneration, diabetic retinopathy, gene delivery-based angiogenic therapy, protein delivery-based angiogenic therapy, stem cell angiogenic therapy, and diabetic retinopathy, cancer that may benefit from the behavior of the nanostructures in the vascular system throughout the body. In addition, the accompanying difficulties and potential future applications of NPs in treating angiogenesis-related diseases and antiangiogenic therapies are discussed. |
format | Online Article Text |
id | pubmed-9636835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-96368352022-11-06 Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process Hoseinzadeh, Ahmad Ghoddusi Johari, Hamed Anbardar, Mohammad Hossein Tayebi, Lobat Vafa, Ehsan Abbasi, Milad Vaez, Ahmad Golchin, Ali Amani, Ali Mohammad Jangjou, Ali Eur J Med Res Review Angiogenesis is a vital biological process involving blood vessels forming from pre-existing vascular systems. This process contributes to various physiological activities, including embryonic development, hair growth, ovulation, menstruation, and the repair and regeneration of damaged tissue. On the other hand, it is essential in treating a wide range of pathological diseases, such as cardiovascular and ischemic diseases, rheumatoid arthritis, malignancies, ophthalmic and retinal diseases, and other chronic conditions. These diseases and disorders are frequently treated by regulating angiogenesis by utilizing a variety of pro-angiogenic or anti-angiogenic agents or molecules by stimulating or suppressing this complicated process, respectively. Nevertheless, many traditional angiogenic therapy techniques suffer from a lack of ability to achieve the intended therapeutic impact because of various constraints. These disadvantages include limited bioavailability, drug resistance, fast elimination, increased price, nonspecificity, and adverse effects. As a result, it is an excellent time for developing various pro- and anti-angiogenic substances that might circumvent the abovementioned restrictions, followed by their efficient use in treating disorders associated with angiogenesis. In recent years, significant progress has been made in different fields of medicine and biology, including therapeutic angiogenesis. Around the world, a multitude of research groups investigated several inorganic or organic nanoparticles (NPs) that had the potential to effectively modify the angiogenesis processes by either enhancing or suppressing the process. Many studies into the processes behind NP-mediated angiogenesis are well described. In this article, we also cover the application of NPs to encourage tissue vascularization as well as their angiogenic and anti-angiogenic effects in the treatment of several disorders, including bone regeneration, peripheral vascular disease, diabetic retinopathy, ischemic stroke, rheumatoid arthritis, post-ischemic cardiovascular injury, age-related macular degeneration, diabetic retinopathy, gene delivery-based angiogenic therapy, protein delivery-based angiogenic therapy, stem cell angiogenic therapy, and diabetic retinopathy, cancer that may benefit from the behavior of the nanostructures in the vascular system throughout the body. In addition, the accompanying difficulties and potential future applications of NPs in treating angiogenesis-related diseases and antiangiogenic therapies are discussed. BioMed Central 2022-11-04 /pmc/articles/PMC9636835/ /pubmed/36333816 http://dx.doi.org/10.1186/s40001-022-00833-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Hoseinzadeh, Ahmad Ghoddusi Johari, Hamed Anbardar, Mohammad Hossein Tayebi, Lobat Vafa, Ehsan Abbasi, Milad Vaez, Ahmad Golchin, Ali Amani, Ali Mohammad Jangjou, Ali Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process |
title | Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process |
title_full | Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process |
title_fullStr | Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process |
title_full_unstemmed | Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process |
title_short | Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process |
title_sort | effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636835/ https://www.ncbi.nlm.nih.gov/pubmed/36333816 http://dx.doi.org/10.1186/s40001-022-00833-6 |
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