Multiple Lytic Bone Lesions Mimicking Langerhans Cell Histiocytosis: A Case of Infantile Mendelian Susceptibility to Mycobacterial Disease due to STAT1 Deficiency

We present the first infantile disseminated Bacillus Calmette-Guérin (BCG) disease case with STAT1 deficiency, which is manifested by multiple Langerhans cell histiocytosis–like osteolytic lesions. The diagnosis of BCG-induced osteomyelitis was not initially considered until the additional biopsy re...

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Detalles Bibliográficos
Autores principales: He, Yingyi, Zhang, Hui, Li, Chunjie, Su, Xiaoling, Gan, Wenting, Wang, Pengfei, Xiao, Weiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636850/
https://www.ncbi.nlm.nih.gov/pubmed/36349275
http://dx.doi.org/10.1093/ofid/ofac533
Descripción
Sumario:We present the first infantile disseminated Bacillus Calmette-Guérin (BCG) disease case with STAT1 deficiency, which is manifested by multiple Langerhans cell histiocytosis–like osteolytic lesions. The diagnosis of BCG-induced osteomyelitis was not initially considered until the additional biopsy revealing granulomatous inflammation, a key pathological diagnostic component for mycobacterial infection.

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