Multiple Lytic Bone Lesions Mimicking Langerhans Cell Histiocytosis: A Case of Infantile Mendelian Susceptibility to Mycobacterial Disease due to STAT1 Deficiency

We present the first infantile disseminated Bacillus Calmette-Guérin (BCG) disease case with STAT1 deficiency, which is manifested by multiple Langerhans cell histiocytosis–like osteolytic lesions. The diagnosis of BCG-induced osteomyelitis was not initially considered until the additional biopsy re...

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Autores principales: He, Yingyi, Zhang, Hui, Li, Chunjie, Su, Xiaoling, Gan, Wenting, Wang, Pengfei, Xiao, Weiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636850/
https://www.ncbi.nlm.nih.gov/pubmed/36349275
http://dx.doi.org/10.1093/ofid/ofac533
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author He, Yingyi
Zhang, Hui
Li, Chunjie
Su, Xiaoling
Gan, Wenting
Wang, Pengfei
Xiao, Weiqiang
author_facet He, Yingyi
Zhang, Hui
Li, Chunjie
Su, Xiaoling
Gan, Wenting
Wang, Pengfei
Xiao, Weiqiang
author_sort He, Yingyi
collection PubMed
description We present the first infantile disseminated Bacillus Calmette-Guérin (BCG) disease case with STAT1 deficiency, which is manifested by multiple Langerhans cell histiocytosis–like osteolytic lesions. The diagnosis of BCG-induced osteomyelitis was not initially considered until the additional biopsy revealing granulomatous inflammation, a key pathological diagnostic component for mycobacterial infection.
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spelling pubmed-96368502022-11-07 Multiple Lytic Bone Lesions Mimicking Langerhans Cell Histiocytosis: A Case of Infantile Mendelian Susceptibility to Mycobacterial Disease due to STAT1 Deficiency He, Yingyi Zhang, Hui Li, Chunjie Su, Xiaoling Gan, Wenting Wang, Pengfei Xiao, Weiqiang Open Forum Infect Dis Brief Report We present the first infantile disseminated Bacillus Calmette-Guérin (BCG) disease case with STAT1 deficiency, which is manifested by multiple Langerhans cell histiocytosis–like osteolytic lesions. The diagnosis of BCG-induced osteomyelitis was not initially considered until the additional biopsy revealing granulomatous inflammation, a key pathological diagnostic component for mycobacterial infection. Oxford University Press 2022-10-11 /pmc/articles/PMC9636850/ /pubmed/36349275 http://dx.doi.org/10.1093/ofid/ofac533 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
He, Yingyi
Zhang, Hui
Li, Chunjie
Su, Xiaoling
Gan, Wenting
Wang, Pengfei
Xiao, Weiqiang
Multiple Lytic Bone Lesions Mimicking Langerhans Cell Histiocytosis: A Case of Infantile Mendelian Susceptibility to Mycobacterial Disease due to STAT1 Deficiency
title Multiple Lytic Bone Lesions Mimicking Langerhans Cell Histiocytosis: A Case of Infantile Mendelian Susceptibility to Mycobacterial Disease due to STAT1 Deficiency
title_full Multiple Lytic Bone Lesions Mimicking Langerhans Cell Histiocytosis: A Case of Infantile Mendelian Susceptibility to Mycobacterial Disease due to STAT1 Deficiency
title_fullStr Multiple Lytic Bone Lesions Mimicking Langerhans Cell Histiocytosis: A Case of Infantile Mendelian Susceptibility to Mycobacterial Disease due to STAT1 Deficiency
title_full_unstemmed Multiple Lytic Bone Lesions Mimicking Langerhans Cell Histiocytosis: A Case of Infantile Mendelian Susceptibility to Mycobacterial Disease due to STAT1 Deficiency
title_short Multiple Lytic Bone Lesions Mimicking Langerhans Cell Histiocytosis: A Case of Infantile Mendelian Susceptibility to Mycobacterial Disease due to STAT1 Deficiency
title_sort multiple lytic bone lesions mimicking langerhans cell histiocytosis: a case of infantile mendelian susceptibility to mycobacterial disease due to stat1 deficiency
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636850/
https://www.ncbi.nlm.nih.gov/pubmed/36349275
http://dx.doi.org/10.1093/ofid/ofac533
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