Cargando…

In vivo Characterization of the Opioid Receptor–Binding Profiles of Samidorphan and Naltrexone in Rats: Comparisons at Clinically Relevant Concentrations

INTRODUCTION: The atypical antipsychotic olanzapine is approved for the treatment of schizophrenia and bipolar I disorder; however, weight gain and metabolic dysregulation associated with olanzapine therapy have limited its clinical utility. In clinical studies, treatment with the combination of ola...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tan, Laura A, Gajipara, Nileshkumar, Sun, Lei, Bacolod, Maria, Zhou, Ying, Namchuk, Mark, Cunningham, Jacobi I
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636859/ https://www.ncbi.nlm.nih.gov/pubmed/36345421 http://dx.doi.org/10.2147/NDT.S373195

Ejemplares similares

Samidorphan mitigates olanzapine-induced weight gain and metabolic dysfunction in rats and non-human primates
por: Cunningham, Jacobi I, et al.
Publicado: (2019)

A Review of Samidorphan: A Novel Opioid Antagonist
por: Chaudhary, Amna Mohyud Din, et al.
Publicado: (2019)

Insulin and glucose metabolism with olanzapine and a combination of olanzapine and samidorphan: exploratory phase 1 results in healthy volunteers
por: Toledo, Frederico G. S., et al.
Publicado: (2021)

Naltrexone Implant for Opioid Use Disorder
por: Edinoff, Amber N., et al.
Publicado: (2021)

Opioid system modulation with buprenorphine/samidorphan combination for major depressive disorder: two randomized controlled studies
por: Fava, Maurizio, et al.
Publicado: (2018)

The Facts and Fiction of Olanzapine-Samidorphan Fixed Dose Combination
por: Das, Nileswar, et al.
Publicado: (2022)

Pharmacological enhancement of naltrexone treatment for opioid dependence: a review
por: Mannelli, Paolo, et al.
Publicado: (2011)

Long-Acting Injectable Naltrexone for the Management of Patients with Opioid Dependence
por: Kjome, Kimberly L., et al.
Publicado: (2011)

Naltrexone extended-release injection: an option for the management of opioid abuse
por: Taylor, Robert, et al.
Publicado: (2011)

Anhedonia to music and mu-opioids: Evidence from the administration of naltrexone
por: Mallik, Adiel, et al.
Publicado: (2017)

The Effects of Low Dose Naltrexone on Opioid Induced Hyperalgesia and Fibromyalgia
por: Jackson, Daniel, et al.
Publicado: (2021)

Chronic Intermittent Sucrose Consumption Facilitates the Ability to Discriminate Opioid Receptor Blockade with Naltrexone in Rats
por: Jewett, David C., et al.
Publicado: (2022)

Use of Remifentanil in a Novel Clinical Paradigm to Characterize Onset and Duration of Opioid Blockade by Samidorphan, a Potent μ-Receptor Antagonist
por: Shram, Megan J., et al.
Publicado: (2015)

Low-Dose Naltrexone Co-Treatment in the Prevention of Opioid-Induced Hyperalgesia
por: Shaheed, Gurneet, et al.
Publicado: (2021)

Kratom-induced transaminitis with subsequent precipitated opioid withdrawal following naltrexone
por: Jensen, Aimee N., et al.
Publicado: (2021)

Characterization of the Pharmacokinetics of Samidorphan in Healthy Volunteers: Absolute Bioavailability and the Effect of Food and Age
por: Kumar, Vipul, et al.
Publicado: (2019)

Combination of Olanzapine and Samidorphan Has No Clinically Significant Effect on the Pharmacokinetics of Lithium or Valproate
por: Sun, Lei, et al.
Publicado: (2019)

Naltrexone/Bupropion: Contrave®; Naltrexone SR/Bupropion SR
Publicado: (2012)

Use of methyl-naltrexone for the treatment of opioid-induced constipation in critical care patients
por: Sawh, SB, et al.
Publicado: (2010)

Effects of Naltrexone on Pain Sensitivity and Mood in Fibromyalgia: No Evidence for Endogenous Opioid Pathophysiology
por: Younger, Jarred W., et al.
Publicado: (2009)

Enhanced Intranasal Absorption of Naltrexone by Dodecyl Maltopyranoside: Implications for the Treatment of Opioid Overdose
por: Krieter, Philip, et al.
Publicado: (2019)

Naltrexone blocks alcohol-induced effects on kappa-opioid receptors in the plasma membrane
por: Terenius, Lars, et al.
Publicado: (2023)

Physiologically‐Based Pharmacokinetic Modeling for Predicting Drug Interactions of a Combination of Olanzapine and Samidorphan
por: Sun, Lei, et al.
Publicado: (2020)

Population Pharmacokinetics of Olanzapine and Samidorphan When Administered in Combination in Healthy Subjects and Patients With Schizophrenia
por: Sun, Lei, et al.
Publicado: (2021)

Combining samidorphan with olanzapine to mitigate weight gain as a side effect in schizophrenia treatment
por: Grywińska, Weronika B., et al.
Publicado: (2023)

Ethanol/Naltrexone Interactions at the mu-Opioid Receptor. CLSM/FCS Study in Live Cells
por: Vukojević, Vladana, et al.
Publicado: (2008)

Effectiveness of Naltrexone in the Prevention of Delayed Respiratory Arrest in Opioid-Naive Methadone-Intoxicated Patients
por: Aghabiklooei, Abbas, et al.
Publicado: (2013)

Treating Opioid Dependence With Injectable Extended-Release Naltrexone (XR-NTX): Who Will Respond?
por: Nunes, Edward V., et al.
Publicado: (2015)

Intranasal Low-Dose Naltrexone Against Opioid Side Effects: A Preclinical Study
por: Micheli, Laura, et al.
Publicado: (2020)

Naltrexone is neuroprotective against traumatic brain injury in mu opioid receptor knockout mice
por: Wang, Yu‐Syuan, et al.
Publicado: (2021)

Comparative Effectiveness Associated With Buprenorphine and Naltrexone in Opioid Use Disorder and Cooccurring Polysubstance Use
por: Xu, Kevin Y., et al.
Publicado: (2022)

Effect of hepatic and renal impairment on the pharmacokinetics of olanzapine and samidorphan given in combination as a bilayer tablet
por: Sun, Lei, et al.
Publicado: (2019)

The effects of naltrexone on retention in treatment and being opioid-free in opioid-dependent people: A systematic review and meta-analysis
por: Zangiabadian, Moein, et al.
Publicado: (2022)

O-Benzoylnaltrexone
por: Yang, Rui, et al.
Publicado: (2013)

Asymmetric synthesis of (–)-naltrexone
por: Dongbang, Sun, et al.
Publicado: (2018)

Comment on “Effectiveness of Naltrexone in the Prevention of Delayed Respiratory Arrest in Opioid-Naive Methadone-Intoxicated Patients”
por: Kessler, Benjamin D., et al.
Publicado: (2014)

Comment on “Effectiveness of Naltrexone in the Prevention of Delayed Respiratory Arrest in Opioid-Naive Methadone-Intoxicated Patients”
por: Aghabiklooei, Abbas, et al.
Publicado: (2015)

Comment on “Review of Case Narratives from Fatal Overdoses Associated with Injectable Naltrexone for Opioid Dependence”
por: Silverman, Bernard, et al.
Publicado: (2018)

Buprenorphine therapy in the setting of induced opioid withdrawal from oral naltrexone: a case report
por: Szczesniak, Laura M., et al.
Publicado: (2020)

Life threatening opioid withdrawal syndrome due to inadvertent naltrexone administration and lifesaving result by clonidine
por: Kurmi, Jayanta, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_mpba65el771nhdn980ptobfnoe