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Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family

American bullfrog (Rana castesbeiana) saxiphilin (RcSxph) is a high-affinity “toxin sponge” protein thought to prevent intoxication by saxitoxin (STX), a lethal bis-guanidinium neurotoxin that causes paralytic shellfish poisoning (PSP) by blocking voltage-gated sodium channels (Na(V)s). How specific...

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Detalles Bibliográficos
Autores principales:	Chen, Zhou, Zakrzewska, Sandra, Hajare, Holly S., Alvarez-Buylla, Aurora, Abderemane-Ali, Fayal, Bogan, Maximiliana, Ramirez, Dave, O’Connell, Lauren A., Du Bois, J., Minor, Daniel L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636910/ https://www.ncbi.nlm.nih.gov/pubmed/36279441 http://dx.doi.org/10.1073/pnas.2210114119

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