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Sleep deprivation and hippocampal ripple disruption after one-session learning eliminate memory expression the next day

Memory reactivation during non–rapid-eye-movement ripples is thought to communicate new information to a systems-wide network and thus can be a key player mediating the positive effect of sleep on memory consolidation. Causal experiments disrupting ripples have only been performed in multiday traini...

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Autores principales: Aleman-Zapata, Adrian, Morris, Richard G. M., Genzel, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636927/
https://www.ncbi.nlm.nih.gov/pubmed/36279444
http://dx.doi.org/10.1073/pnas.2123424119
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author Aleman-Zapata, Adrian
Morris, Richard G. M.
Genzel, Lisa
author_facet Aleman-Zapata, Adrian
Morris, Richard G. M.
Genzel, Lisa
author_sort Aleman-Zapata, Adrian
collection PubMed
description Memory reactivation during non–rapid-eye-movement ripples is thought to communicate new information to a systems-wide network and thus can be a key player mediating the positive effect of sleep on memory consolidation. Causal experiments disrupting ripples have only been performed in multiday training paradigms, which decrease but do not eliminate memory performance, and no comparison with sleep deprivation has been made. To enable such investigations, we developed a one-session learning paradigm in a Plusmaze and show that disruption of either sleep with gentle handling or hippocampal ripples with electrical stimulation impaired long-term memory. Furthermore, we detected hippocampal ripples and parietal high-frequency oscillations after different behaviors, and a bimodal frequency distribution in the cortical events was observed. Faster cortical high-frequency oscillations increased after normal learning, a change not seen in the hippocampal ripple-disruption condition, consistent with these having a role in memory consolidation.
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spelling pubmed-96369272022-11-06 Sleep deprivation and hippocampal ripple disruption after one-session learning eliminate memory expression the next day Aleman-Zapata, Adrian Morris, Richard G. M. Genzel, Lisa Proc Natl Acad Sci U S A Social Sciences Memory reactivation during non–rapid-eye-movement ripples is thought to communicate new information to a systems-wide network and thus can be a key player mediating the positive effect of sleep on memory consolidation. Causal experiments disrupting ripples have only been performed in multiday training paradigms, which decrease but do not eliminate memory performance, and no comparison with sleep deprivation has been made. To enable such investigations, we developed a one-session learning paradigm in a Plusmaze and show that disruption of either sleep with gentle handling or hippocampal ripples with electrical stimulation impaired long-term memory. Furthermore, we detected hippocampal ripples and parietal high-frequency oscillations after different behaviors, and a bimodal frequency distribution in the cortical events was observed. Faster cortical high-frequency oscillations increased after normal learning, a change not seen in the hippocampal ripple-disruption condition, consistent with these having a role in memory consolidation. National Academy of Sciences 2022-10-24 2022-11-01 /pmc/articles/PMC9636927/ /pubmed/36279444 http://dx.doi.org/10.1073/pnas.2123424119 Text en Copyright © 2022 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Social Sciences
Aleman-Zapata, Adrian
Morris, Richard G. M.
Genzel, Lisa
Sleep deprivation and hippocampal ripple disruption after one-session learning eliminate memory expression the next day
title Sleep deprivation and hippocampal ripple disruption after one-session learning eliminate memory expression the next day
title_full Sleep deprivation and hippocampal ripple disruption after one-session learning eliminate memory expression the next day
title_fullStr Sleep deprivation and hippocampal ripple disruption after one-session learning eliminate memory expression the next day
title_full_unstemmed Sleep deprivation and hippocampal ripple disruption after one-session learning eliminate memory expression the next day
title_short Sleep deprivation and hippocampal ripple disruption after one-session learning eliminate memory expression the next day
title_sort sleep deprivation and hippocampal ripple disruption after one-session learning eliminate memory expression the next day
topic Social Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636927/
https://www.ncbi.nlm.nih.gov/pubmed/36279444
http://dx.doi.org/10.1073/pnas.2123424119
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