Cargando…

A robust core architecture of functional brain networks supports topological resilience and cognitive performance in middle- and old-aged adults

Aging is associated with gradual changes in cognition, yet some individuals exhibit protection against age-related cognitive decline. The topological characteristics of brain networks that promote protection against cognitive decline in aging are unknown. Here, we investigated whether the robustness...

Descripción completa

Detalles Bibliográficos
Autores principales: Stanford, William C., Mucha, Peter J., Dayan, Eran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636938/
https://www.ncbi.nlm.nih.gov/pubmed/36282912
http://dx.doi.org/10.1073/pnas.2203682119
_version_ 1784825066258694144
author Stanford, William C.
Mucha, Peter J.
Dayan, Eran
author_facet Stanford, William C.
Mucha, Peter J.
Dayan, Eran
author_sort Stanford, William C.
collection PubMed
description Aging is associated with gradual changes in cognition, yet some individuals exhibit protection against age-related cognitive decline. The topological characteristics of brain networks that promote protection against cognitive decline in aging are unknown. Here, we investigated whether the robustness and resilience of brain networks, queried via the delineation of the brain’s core network structure, relate to age and cognitive performance in a cross-sectional dataset of healthy middle- and old-aged adults (n = 478, ages 40 to 90 y). First, we decomposed each subject’s functional brain network using k-shell decomposition and found that age was negatively associated with robust core network structures. Next, we perturbed these networks, via attack simulations, and found that resilience of core brain network nodes also declined in relationship to age. We then partitioned our dataset into middle- (ages 40 to 65 y, n = 300) and old- (ages 65 to 90 y, n = 178) aged subjects and observed that older individuals had less robust core connectivity and resilience. Following these analyses, we found that episodic memory was positively related to robust connectivity and core resilience, particularly within the default node, limbic, and frontoparietal control networks. Importantly, we found that age-related differences in episodic memory were positively related to core resilience, which indicates a potential role for core resilience in protection against cognitive decline. Together, these findings suggest that robust core connectivity and resilience of brain networks could facilitate high cognitive performance in aging.
format Online
Article
Text
id pubmed-9636938
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher National Academy of Sciences
record_format MEDLINE/PubMed
spelling pubmed-96369382023-04-25 A robust core architecture of functional brain networks supports topological resilience and cognitive performance in middle- and old-aged adults Stanford, William C. Mucha, Peter J. Dayan, Eran Proc Natl Acad Sci U S A Biological Sciences Aging is associated with gradual changes in cognition, yet some individuals exhibit protection against age-related cognitive decline. The topological characteristics of brain networks that promote protection against cognitive decline in aging are unknown. Here, we investigated whether the robustness and resilience of brain networks, queried via the delineation of the brain’s core network structure, relate to age and cognitive performance in a cross-sectional dataset of healthy middle- and old-aged adults (n = 478, ages 40 to 90 y). First, we decomposed each subject’s functional brain network using k-shell decomposition and found that age was negatively associated with robust core network structures. Next, we perturbed these networks, via attack simulations, and found that resilience of core brain network nodes also declined in relationship to age. We then partitioned our dataset into middle- (ages 40 to 65 y, n = 300) and old- (ages 65 to 90 y, n = 178) aged subjects and observed that older individuals had less robust core connectivity and resilience. Following these analyses, we found that episodic memory was positively related to robust connectivity and core resilience, particularly within the default node, limbic, and frontoparietal control networks. Importantly, we found that age-related differences in episodic memory were positively related to core resilience, which indicates a potential role for core resilience in protection against cognitive decline. Together, these findings suggest that robust core connectivity and resilience of brain networks could facilitate high cognitive performance in aging. National Academy of Sciences 2022-10-25 2022-11-01 /pmc/articles/PMC9636938/ /pubmed/36282912 http://dx.doi.org/10.1073/pnas.2203682119 Text en Copyright © 2022 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Stanford, William C.
Mucha, Peter J.
Dayan, Eran
A robust core architecture of functional brain networks supports topological resilience and cognitive performance in middle- and old-aged adults
title A robust core architecture of functional brain networks supports topological resilience and cognitive performance in middle- and old-aged adults
title_full A robust core architecture of functional brain networks supports topological resilience and cognitive performance in middle- and old-aged adults
title_fullStr A robust core architecture of functional brain networks supports topological resilience and cognitive performance in middle- and old-aged adults
title_full_unstemmed A robust core architecture of functional brain networks supports topological resilience and cognitive performance in middle- and old-aged adults
title_short A robust core architecture of functional brain networks supports topological resilience and cognitive performance in middle- and old-aged adults
title_sort robust core architecture of functional brain networks supports topological resilience and cognitive performance in middle- and old-aged adults
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636938/
https://www.ncbi.nlm.nih.gov/pubmed/36282912
http://dx.doi.org/10.1073/pnas.2203682119
work_keys_str_mv AT stanfordwilliamc arobustcorearchitectureoffunctionalbrainnetworkssupportstopologicalresilienceandcognitiveperformanceinmiddleandoldagedadults
AT muchapeterj arobustcorearchitectureoffunctionalbrainnetworkssupportstopologicalresilienceandcognitiveperformanceinmiddleandoldagedadults
AT dayaneran arobustcorearchitectureoffunctionalbrainnetworkssupportstopologicalresilienceandcognitiveperformanceinmiddleandoldagedadults
AT stanfordwilliamc robustcorearchitectureoffunctionalbrainnetworkssupportstopologicalresilienceandcognitiveperformanceinmiddleandoldagedadults
AT muchapeterj robustcorearchitectureoffunctionalbrainnetworkssupportstopologicalresilienceandcognitiveperformanceinmiddleandoldagedadults
AT dayaneran robustcorearchitectureoffunctionalbrainnetworkssupportstopologicalresilienceandcognitiveperformanceinmiddleandoldagedadults